2023 Fiscal Year Final Research Report
Elucidation of mesenchymal stem cell signaling by exosomes and development of new bone regeneration technology
| Project/Area Number |
18K16995
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 56070:Plastic and reconstructive surgery-related
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2024-03-31
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| Keywords | 骨組織再生 / 細胞外小胞 / エクソソーム / miRNA |
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| Outline of Final Research Achievements |
There have been various reports on exosomes derived from human bone tissue-derived mesenchymal cells. We investigated the role of exosomes in bone regeneration. Exosomes were collected from the culture supernatant of human bone tissue-derived mesenchymal cells in two groups, bone differentiation-induced and non-differentiation-induced, and the miRNAs contained in the exosomes were analyzed. The results suggested that miRNAs may play an important role in bone morphogenesis.
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| Free Research Field |
形成外科学、再建外科学、再生医療
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| Academic Significance and Societal Importance of the Research Achievements |
細胞から分泌されるエクソソームを含む細胞外小胞については診断学、創薬などで多くの報告がされている。細胞外小胞は、細胞間情報伝達をおこなっているが不明な点も多く、骨形成における細胞外小胞の働きを解明することにより、効率的な骨形成が行えるようになるとともに、細胞の増殖など細胞外小胞の他の働きも解明できる可能性がある。これにより効率的で、細胞を用いない安全な再生医療を行える可能性がある。
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