Study of cinnamon components about the inhibitory effect on periodontal disease

2020 Fiscal Year Final Research Report

• Project/Area Number: 18K17043
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57030:Conservative dentistry-related
• Research Institution: Niigata University
• Principal Investigator: Nonaka Yukari 新潟大学, 医歯学系, 助教 (40710520)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Keywords: 歯周治療学

Outline of Final Research Achievements

The aim of this study was to elucidate the antibacterial and anti-inflammatory activities of a component of cinnamon, and to contribute to the development of a new therapeutic agent for periodontal disease.
The antibacterial activity against typical periodontopathic bacteria was clarified. In addition, a component of cinnamon showed anti-inflammatory activity against the production of inflammatory cytokines induced by LPS stimulation from periodontopathic bacteria. Furthermore, the inhibitory effect on alveolar bone resorption was demonstrated using a mouse model of periodontal disease.
These results suggest the possibility of applying a component of cinnamon as a novel periodontal drug.

Free Research Field

歯周病学

Academic Significance and Societal Importance of the Research Achievements

歯周病の有病率を下げ歯の喪失を防ぐことは、国民の健康寿命の延伸につながる。歯周病は歯周病原細菌の感染によって引き起こされ、その治療は機械的なプラークの除去に加えて抗菌薬の投与も行われる。しかし、薬剤耐性菌の問題から、既存の抗菌薬に代わる歯周病予防・治療薬の開発が必要とされている。本研究の結果から，シナモン成分について新規の歯周病治療薬開発の基礎となるデータが得られた。本研究の創造性は、食品由来という安心感による普及効果が期待できる抗歯周病医薬の開発にある。既存の抗菌薬の代替または補助としての発展の可能性があり，その社会的意義は大きい。