A cross-over trial on efficacy of bi-block appliance in patients with obstructive sleep apnea

2022 Fiscal Year Final Research Report

• Project/Area Number: 18K17140
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57050:Prosthodontics-related
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: ISHIYAMA Hiroyuki 東京医科歯科大学, 東京医科歯科大学病院, 特任助教 (50782273)
• Project Period (FY): 2018-04-01 – 2023-03-31
• Keywords: 閉塞性睡眠時無呼吸 / 口腔内装置 / 上下一体型 / 上下分離型 / 治療効果 / 患者満足度 / 副作用 / QOL

Outline of Final Research Achievements

Oral appliance (OA) therapy for obstructive sleep apnea (OSA) can be structurally classified into mono-block and bi-block OA. The aim of this study was to conduct a systematic review and meta-analysis to determine which structure is more effective before proceeding with a prospective, comparative study of mono-block OA and bi-block OA. After secondary screening, two articles remained, and a meta-analysis showed that mono-block OA significantly reduced the apnea-hypopnea index (AHI) and significantly increased patient satisfaction compared to bi-block OA. Therefore, it was shown that mono-block OA was more effective than bi-block OA in OA therapy for OSA patients.

Free Research Field

歯科補綴学, 睡眠歯学

Academic Significance and Societal Importance of the Research Achievements

OAの構造について, これまで一体型, 分離型どちらが有効かについて議論が分かれていたが, 本研究の結果は臨床医がOA療法を際, 装置の設計を考える上での指標となる. 一体型OAはOSA治療効果だけでなく, 患者満足度も良いという事から, 総合的にも有効な装置である事が示された.