Pharmacokinetic analysis of tumors in the maxillofacial region using Dual Energy CT

2021 Fiscal Year Final Research Report

• Project/Area Number: 18K17170
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57060:Surgical dentistry-related
• Research Institution: Kyushu University
• Principal Investigator: KITAMOTO ERINA 九州大学, 歯学研究院, 助教 (40760476)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Keywords: dual energy CT / 顎顔面領域 / 扁平上皮癌 / 頸部リンパ節転移

Outline of Final Research Achievements

We established a Dual Energy CT (DECT) protocol in the maxillofacial region and investigated whether parameters calculated from DECT images are effective in the diagnosis of metastatic lymph nodes of squamous cell carcinoma.
Cervical lymph nodes larger than 5 mm were included in the study to determine the variation in CT values at 40, 70, and 100 keV and iodine content within the lymph nodes, and to correlate them with pathology. Metastatic lymph nodes tended to have significantly smaller contrast uptake than non-metastatic nodes, suggesting that DECT is likely to be associated with pathological changes within metastatic lymph nodes.

Free Research Field

歯科放射線

Academic Significance and Societal Importance of the Research Achievements

顎顔面領域において、DECT画像から算出したパラメータが扁平上皮癌の転移リンパ節の診断に有用である可能性が示唆された。