2021 Fiscal Year Research-status Report
ラマン分光法を用いた破骨細胞の分化・生理機能解析と顎骨壊死の病態解明への応用
| Project/Area Number |
18K17175
|
|---|
| Research Institution | Kyoto Institute of Technology |
|---|
Principal Investigator |
Marin Elia 京都工芸繊維大学, 材料化学系, 助教 (10814014)
|
|---|
| Project Period (FY) |
2018-04-01 – 2023-03-31
|
| Keywords | ラマン |
|---|
| Outline of Annual Research Achievements |
First, the Raman spectra of osteonecrotic bone samples from different patients has been obtained an analyzed, also using statistical approaches. It has been observed that the Raman spectra of osteonecrotic tissue is influenced by the cause of the osteonecrosis, with different results between osteonecrosis caused by alcohol and osteonecrosis caused by steroids. The results have been published on a scientific paper. For the second part of the project, Raman spectroscopy has been successfully used to evaluate the effects of alendronate on the differentiation of osteoclasts from progenitor RAW cells on two different substrates: ortocalcium phosphate and dentine. We also observed that the differentiation induced by RANKL is impaired but not inhibited by the addition of 2ng/mL of alendronate.
|
| Current Status of Research Progress |
Current Status of Research Progress
3: Progress in research has been slightly delayed.
Reason
Because of the Coronavirus pandemic, the research has been delayed a few months but will be completed within 2022.
|
| Strategy for Future Research Activity |
All experimental data have been achieved, we will now proceed with more statistical analysis and data comparison.
|
| Causes of Carryover |
The remaing budget will be used for expenses related to storing the research results and publishing the data
|
Research Products
(3 results)
