Development of antibacterial additive manufacturing titanium artificial bone using HDSI method.

2022 Fiscal Year Final Research Report

• Project/Area Number: 18K17185
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57060:Surgical dentistry-related
• Research Institution: Osaka Medical and Pharmaceutical University
• Principal Investigator: Yamamoto Kayoko 大阪医科薬科大学, 医学部, 助教 (70814094)
• Project Period (FY): 2018-04-01 – 2023-03-31
• Keywords: 生体材料 / 人工骨 / バイオマテリアル

Outline of Final Research Achievements

Autogenous or artificial bone graft has been operated for bone defects caused by tumors and traumas. However, autogenous bone graft has been considered to have several disadvantages such as the limited quantities available, donor-site morbidity and postoperative inflammation. Whereas artificial bone graft has not had sufficient strength or sculpted various shapes. These problems could make it difficult to reproduce the appearance and could cause postoperative inflammation.
In this study, Selective Laser Melting (SLM) titanium artificial bone which is sculpted in various shapes has been manufactured and applied various surfaces treatment to develop new bioactive titanium artificial bone and new bone cement to be fixed.

Free Research Field

バイオマテリアル

Academic Significance and Societal Importance of the Research Achievements

この研究では、選択的レーザー溶融法(SLM法)を用いて、いかなる形態の骨欠損部にも適合可能な積層造形チタン人工骨を作製、さらに骨再生能を持つ表面処理を施した生体活性型チタン人工骨と人工骨固定のための新規骨セメントの開発を行い実用化のための基礎データとした。すでに基礎医療分野で研究されている、金属粒子に抗菌力を付与する最新技術をハイブリッドさせ、人工骨のコアマテリアルである純チタン微粒子に抗菌力を付与することで、世界初の抗菌力を有するチタン人工骨および骨セメントの開発が可能であると考えている。