Mechanism of lymph node stromal cells and immune tolerance in lymph node metastasis of oral cancer

2020 Fiscal Year Final Research Report

• Project/Area Number: 18K17186
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57060:Surgical dentistry-related
• Research Institution: Hyogo Medical University
• Principal Investigator: Yoshikawa Kyohei 兵庫医科大学, 医学部, 助教 (00727480)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Keywords: 口腔扁平上皮癌 / 頸部リンパ節転移 / エクソソーム

Outline of Final Research Achievements

We established cell lines from the dissected metastatic cervical lymph nodes of an oral squamous cell carcinoma patient. In recent years, the role of exosome secreted by cancer cells is noticed and we made a success for extracting it from oral squamous cell carcinoma cell line. Furthermore, high expressions of exosome marker were seen in western blot analyzing. From these results, functional analysis of exosome could be a new information for the mechanism of cancer metastasis and therapeutic target.

Free Research Field

口腔癌

Academic Significance and Societal Importance of the Research Achievements

口腔癌では「頸部転移」が重要な予後因子であり、しばしば予後不良となる症例に遭遇することも多く、口腔癌の治療成績を向上させるためには、エクソソームの機能解析をさらにすすめることで、癌の増殖や浸潤、転移に対する新たな治療戦略を見いだすことができる可能性が高いと考えられる。