Elucidation of factors related to diversity of invasive form of ameloblastoma using animal transplantation model

2019 Fiscal Year Final Research Report

• Project/Area Number: 18K17230
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57060:Surgical dentistry-related
• Research Institution: Kagoshima University
• Principal Investigator: FUCHIGAMI Takao 鹿児島大学, 医歯学域鹿児島大学病院, 助教 (40772439)
• Project Period (FY): 2018-04-01 – 2020-03-31
• Keywords: エナメル上皮腫 / 歯原性腫瘍 / 動物モデル / 三次元培養

Outline of Final Research Achievements

The purpose of this study plan was to obtain novel findings that would help on realizing new treatment strategy for ameloblastoma. Immortalized human ameloblastoma cell lines derived from two pathological types, AM-1 (plexiform) and AM-3 (follicular), were transplanted with Matrigel into immunodeficient mice, and we established stable animal experimental model of ameloblastoma. This model enables the evaluation of ameloblastoma in an environment close to the actual lesion, and enables experiments to develope a novel strategic treatment for various types of ameloblastoma.

Free Research Field

口腔外科学

Academic Significance and Societal Importance of the Research Achievements

エナメル上皮腫の安定した動物実験モデルは世界的にも報告がなく、その実現は今まで困難であった生体内でのエナメル上皮腫の動態評価を可能とし、本腫瘍の病態解明に非常に有益なものになると考える。本研究の成果から、エナメル上皮腫の浸潤発育様式に関わる因子を同定できれば、病態の異なる様々なタイプのエナメル上皮腫に対する戦略的な治療法の実現が可能であると考える。