Research on improvement of exercise tolerance in patients with heart failure with preserved ejection fraction by combined non-invasive intermittent positive pressure ventilation

2021 Fiscal Year Final Research Report

• Project/Area Number: 18K17704
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 59010:Rehabilitation science-related
• Research Institution: The Tazuke Kofukai
• Principal Investigator: Kamisaka Kenta 公益財団法人田附興風会, 医学研究所 保健・健康研究部, 研究員 (40814207)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Keywords: 収縮能が保たれた心不全 / 体重減少 / 予後

Outline of Final Research Achievements

Heart failure patients with preserved ejection fraction (HFpEF) are increasing as the population ages. Lower exercise tolerance in patients with HFpEF is a poor prognostic factor after discharge from the hospital. This study was planned to examine the effect of exercise therapy in combination with noninvasive intermittent positive pressure ventilation (NIPPV) on improving exercise tolerance. However, use of NIPPV became difficult due to the COVID-19 epidemic. Therefore, we conducted a subanalysis of a prospective cohort study of patients with HFpEF to examine the poor prognostic factors after discharge from the hospital. We found that post-discharge weight loss is a poor prognostic factor for patients with HFpEF.

Free Research Field

リハビリテーション

Academic Significance and Societal Importance of the Research Achievements

本研究の当初の目的とした収縮能が保たれた心不全患者（HFpEF）に対して、非侵襲的間欠的陽圧換気療法で呼吸をサポートすることによる運動耐容能改善効果は明らかとはならなかった。しかし、高齢かつ併存疾患を多く有するHFpEF患者において、退院後の体重減少が新たな予後因子として明らかとなった。このことは、HFpEF患者の退院後の予後悪化を防ぐための新たな方策を開発する上で重要であると考える。今後、HFpEF患者の予後を改善させるための包括的な介入方策の立案が必要と考えられる。