Investigation of the mechanism of immobilization-induced pain and development of the preventive and therapeutic strategies

2019 Fiscal Year Final Research Report

• Project/Area Number: 18K17734
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 59010:Rehabilitation science-related
• Research Institution: Niigata University of Health and Welfare
• Principal Investigator: HAMAUE Yohei 新潟医療福祉大学, リハビリテーション学部, 助教 (20756374)
• Project Period (FY): 2018-04-01 – 2020-03-31
• Keywords: 不活動 / 痛み / CGRP

Outline of Final Research Achievements

The purpose of this study was to investigate the induction of hyperalgesia in the joint immobilization-induced pain model in rats. Rcently, experimental limb immobilization has been shown to cause mechanical nociceptive hypersensitivities in humans and animals. However, the mechanism underlying immobilization-induced pain remains unclear and there are no reports on peripheral nerve system. In the present study, immobilization-induced mechanical and thermal hypersensitivity was inhibited by administration of the selective CGRP-receptor antagonist. The result suggested that increase of CGRP in peripheral tissues contributed to immobilization-induced hypersensitivity.

Free Research Field

リハビリテーション科学

Academic Significance and Societal Importance of the Research Achievements

ギプス固定などに伴う四肢の一部の不動化は、末梢組織の変調をきたすことにより痛みが生じることが推察される。本研究は、不活動性疼痛の末梢メカニズム解明の一端を担っており、さらに治療開発や新規薬剤開発を進めるうえで十分に意義があると考えられる。