Elucidation of the aging mechanism in skeletal muscle stem cells

2020 Fiscal Year Final Research Report

• Project/Area Number: 18K17857
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 59020:Sports sciences-related
• Research Institution: Kumamoto University
• Principal Investigator: Kitajima Yasuo 熊本大学, 発生医学研究所, 助教 (70734416)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Keywords: 骨格筋 / 筋再生 / 筋幹細胞 / タンパク分解系 / 老化

Outline of Final Research Achievements

In this study, we focused on the proteasome, the main proteolytic system, to elucidate its relationship to aging in muscle stem cells. Proteasome dysfunction in muscle stem cells resulted in a decrease in muscle stem cells due to an increase in the aging-related p53 protein. The p53 gene deletion in muscle stem cell-specific proteasome dysfunction mice did not rescue the number of muscle stem cells. These results suggest that there are different mechanisms for aging-related p53 in vivo and vitro.

Free Research Field

骨格筋生物学

Academic Significance and Societal Importance of the Research Achievements

筋幹細胞におけるタンパク分解系の機能不全は、老化マーカーであるp53の増加をもたらした。これにより、筋幹細胞において、タンパク分解系と老化が関係していることが示された。これらの成果は、筋幹細胞と老化をつなぐ重要な知見を提供し、今後の老化研究の発展につながる可能性がある。