Elucidation of the mechanism of improvement of thermogenic function by exercise training focusing on the immune system

2020 Fiscal Year Final Research Report

• Project/Area Number: 18K17860
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 59020:Sports sciences-related
• Research Institution: Chiba Institute of Technology
• Principal Investigator: Kawanishi Noriaki 千葉工業大学, 先進工学部, 准教授 (00706533)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Keywords: 脂肪組織 / 熱産生機能 / 運動トレーニング / 好中球

Outline of Final Research Achievements

In this study, it was examined the role of neutrophils in improving the thermogenic function in adipose tissue by exercise training. Acute endurance exercise increased the mRNA expression of Metrnl in skeletal muscle, but inhibition of neutrophil infiltration did not affect Metrnl mRNA expression in skeletal muscle. In addition, voluntary exercise training increased the mRNA expression of PGC-1, but inhibition of neutrophil infiltration did not affect PGC-1 mRNA expression in skeletal muscle. Therefore, it is possible that neutrophils are not involved in changes in the thermogenic function of adipose tissue by exercise training.

Free Research Field

スポーツ科学

Academic Significance and Societal Importance of the Research Achievements

運動は脂肪組織の熱産生機能を向上させることから、肥満の予防あるいは改善の効果が期待されている。本研究により、運動による熱産生機能の変動の分子メカニズムの解明を進めることによって、効果的な運動方法を開発することが可能となる。