2020 Fiscal Year Annual Research Report
Mechanisms of low-dose/low-dose-rate radiation-induced cardiovascular disease
| Project/Area Number |
18K18194
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| Research Institution | Hiroshima University |
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Principal Investigator |
ZAHARIEVA ELENA 広島大学, 原爆放射線医科学研究所, 研究員 (30766697)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Keywords | low dose rate radiation / chronic radiation / heart disease risk / endothelial dysfunction / chronic inflammation / endothelial senescence |
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| Outline of Annual Research Achievements |
We explored the mechanisms of radiation induced chronic inflammation in human cells and in mouse models. We showed that vascular endothelial cells are sensitive to radiation exposure, and following low doses/dose rates exhibit growth arrest and robust Senescence Associated Secretory Phenotype. The significant increase in endothelial senescence leads to abnormal inflammatory phenotype and severe disruption of endothelial functions. Inhibition or knock-down of inflammatory regulators can abrogate senescence-associated inflammatory signaling, but do not affect entering senescence and cannot rescue the normal functioning of the endothelium. We also explored the cell composition of mouse aortas and the cytokine profile of irradiated LDR-/- mice to assess the in vivo relevance of these findings.
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