2019 Fiscal Year Annual Research Report
Establishment of a verification and validation framework for the computational fluid dynamics simulations of intracranial aneurysm hemodynamics
| Project/Area Number |
18K18356
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| Research Institution | Tohoku University |
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Principal Investigator |
TUPIN SIMON 東北大学, 流体科学研究所, 特任助教 (40816394)
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| Project Period (FY) |
2018-04-01 – 2020-03-31
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| Keywords | Intracranial Aneurysms / V&V / PIV / DNS |
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| Outline of Annual Research Achievements |
Based on the methodology developed previously, two averaged geometries representing different intracranial aneurysm types (sidewall anneurysm on the internal carotid artery and bifurcation aneurysm at the end of the middle cerebral artery) were computed using patient-specific geometries obtained from the hospital. Particle Image Velocimetry (PIV) experiments were conducted on those models to image the intra-aneurysmal flow. Results were compared to Direct Numerical Simulations (DNS) and Large Eddy Simulations (LES) to investigate in silico reliability in the study of aneurysmal flow. Additionnal DNS were performed to elucidate the difference between using Newtonian and non-Newtonian viscosity.
Other studies related to vascular hemodynamics were also performed. A straight lumen geometry was used to experimentally study the transition to turbulence in pulsatile flow by means of PIV. In addition, an idealized sidewall aneurysmal geometry was fabricated in rigid and elastic models to study the effect of compliance on intra-aneurysmal flow. Finally, the geometrical averaging methodology was applied to study the aortic geometry of healthy volunteers.
The results of these studies have been presented at various conferences and several manuscripts are currently under review. Once published, the results of this project will be made available to the biofluid dynamics research community as an online database.
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