Establishment of a verification and validation framework for the computational fluid dynamics simulations of intracranial aneurysm hemodynamics

2019 Fiscal Year Final Research Report

• Project/Area Number: 18K18356
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 90110:Biomedical engineering-related
• Research Institution: Tohoku University
• Principal Investigator: Tupin Simon 東北大学, 流体科学研究所, 特任助教 (40816394)
• Project Period (FY): 2018-04-01 – 2020-03-31
• Keywords: Intracranial Aneurysm / V&V / DNS / PIV

Outline of Final Research Achievements

The purpose of this project was to establish a verification and validation (V&V) framework in order to standardize the CFD simulations of intracranial aneurysms (IA) which are essential to develop stents, coils and flow diverters used in IA management. The proposed V&V framework was developed using idealized and generalized models based on patient-specific populations. Direct Numerical Simulation (DNS) were performed and simulated hemodynamics were validated using Particle Image Velocimetry (PIV) experiments. Effects of viscosity, wall compliance and flow models on intra-aneurysmal hemodynamics were investigated. Results of this project will be made available as a database to the biofluid dynamics research community.

Free Research Field

Biomedical Engineering

Academic Significance and Societal Importance of the Research Achievements

The verification and validation framework developed in this project is the first standard for the use of computational fluid dynamics simulations in the hemodynamic analysis of intracranial aneurysms. Available to the research community, it aims to improve the accuracy of CFD studies.