2020 Fiscal Year Annual Research Report
Reticuloendothelial system blockade by PEG-oligo(amino acid) block copolymers: A strategy for functional tuning of nanomedicine pharmacokinetics
| Project/Area Number |
18K18393
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| Research Institution | Kawasaki Institute of Industrial Promotion Innovation Center of NanoMedicine |
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Principal Investigator |
ディリサラ アンジャネユル 公益財団法人川崎市産業振興財団(ナノ医療イノベーションセンター), ナノ医療イノベーションセンター, 研究員 (70794353)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Keywords | RES blockade / PEG coating to liver / Two-arm-PEG-peptide / Bile clearance / Retargeting nanomedicine |
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| Outline of Annual Research Achievements |
A single issue of systemically injected nanomedicines is nonspecific elimination by liver scavenger wall, which substantially decreasing the delivery efficiency at target tissues. We addressed this issue by in situ stealth coating of scavenger wall using 1- or 2-armed poly(ethylene glycol) (PEG)-oligo(L-lysine). PEG-OligoLys selectively coat the scavenger wall, leaving other tissue endothelium uncoated, thus, accessible to nanomedicine extravasation. Interestingly, 2-arm-PEG-OligoLys was cleared from wall to bile within hours, while 1-arm-PEG-OligoLys persisted at the wall. Such transient and selective stealth coating by 2-arm-PEG-OligoLys effectively suppressed the elimination of nonviral and viral gene vectors by scavenger wall, thereby boosting their gene transduction at target organs.
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Research Products
(6 results)
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[Journal Article] Transient stealth coating of liver sinusoidal wall by anchoring two-armed PEG for retargeting nanomedicines2020
Author(s)
Anjaneyulu Dirisala, Satoshi Uchida, Kazuko Toh, Junjie Li, Shigehito Osawa, Theofilus A Tockary, Xueying Liu, Saed Abbasi, Kotaro Hayashi, Yuki Mochida, Shigeto Fukushima, Hiroaki Kinoh, Kensuke Osada, Kazunori Kataoka
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Journal Title
Science Advances
Volume: 6 (26)
Pages: eabb8133
DOI
Open Access / Int'l Joint Research
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[Journal Article] Dual-sensitive nanomicelles enhancing systemic delivery of therapeutically active antibodies specifically into the brain2020
Author(s)
Jinbing Xie, Daniel Gonzalez-Carter, Theofilus A Tockary, Noriko Nakamura, Yonger Xue, Makoto Nakakido, Hiroki Akiba, Anjaneyulu Dirisala, Xueying Liu, Kazuko Toh, Tao Yang, Zengtao Wang, Shigeto Fukushima, Junjie Li, Sabina Quader, Kouhei Tsumoto, Takanori Yokota, Yasutaka Anraku, Kazunori Kataoka
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Journal Title
ACS nano
Volume: 14 (6)
Pages: 6729-6742
DOI
Int'l Joint Research
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