Is it possible to lower the rotational barrier of axially chiral biarlys?

2020 Fiscal Year Final Research Report

• Project/Area Number: 18K19084
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 33:Organic chemistry and related fields
• Research Institution: Gakushuin University
• Principal Investigator: AKIYAMA TAKAHIKO 学習院大学, 理学部, 教授 (60202553)
• Project Period (FY): 2018-06-29 – 2021-03-31
• Keywords: 不斉合成 / 軸性不斉化合物 / ビアリール / 回転障壁 / 不斉触媒 / 不斉触媒反応

Outline of Final Research Achievements

Biaryls bearing multiple substituents at the o-positions may generate atropisomers because the rotational barriers of the single of the biaryl become higher. The axially chiral compounds are frequently found in chiral ligands, chiral catalysts, and biologically active compounds. We tried to lower the rotational barrier of the axially chiral compounds.

Free Research Field

有機合成化学

Academic Significance and Societal Importance of the Research Achievements

ビアリール化合物は，不斉配位子，キラル触媒等，不斉触媒反応において数多く用いられている。これらの軸性不斉化合物の回転障壁を下げることができれば，新たな不斉触媒反応の開発につながる可能性があり，学術的に意義があると考えられる。また，それにより，新たな合成法が開拓できれば，医薬品産業への貢献も期待できる。