2020 Fiscal Year Final Research Report
Transcriptional regulation of nuclear receptor Nurr1 in dopaminergic neurons for neuronal disease treatments
| Project/Area Number |
18K19147
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 37:Biomolecular chemistry and related fields
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2018-06-29 – 2021-03-31
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| Keywords | 蛋白質 / 発現制御 / 生体分子 / 生理活性 / 受容体化学 / 分子認識 / タンパク質 |
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| Outline of Final Research Achievements |
Parkinson’s disease is characterized by loss of dopaminergic neurons. L-dopa is used for treatment cure; however, no drugs for permanent cure of this disease have be developed yet. A nuclear receptor, nuclear receptor related 1 (Nurr1), is able to generate directly functional dopaminergic neurons from fibroblasts. Small molecules to control the Nurr1 function will be potent candidate for permanent cure of Parkinson’s disease. We found small molecules affecting Nurr1 transcriptional activity and these molecules will be useful for the future drug development.
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| Free Research Field |
生物化学
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| Academic Significance and Societal Importance of the Research Achievements |
パーキンソン病は高齢者に発症することが多い。すべての人が健康に生きるために、この根治できる薬が社会的に強く望まれている。本課題の遂行により、核内受容体Nurr1の転写活性を変化させ、神経伸長に影響する化合物を見出した。さらにNurr1に結合するペプチドの設計合成に成就した。これらは、パーキンソン病の根治薬開発のために重要な成果である。
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