Revelation of the neuronal mechanism of motor learning using the methods to express genes in particular neuronal pathways

2020 Fiscal Year Final Research Report

• Project/Area Number: 18K19371
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 46:Neuroscience and related fields
• Research Institution: Institute of Physical and Chemical Research (2019-2020); The University of Tokyo (2018)
• Principal Investigator: Masamizu Yoshito 国立研究開発法人理化学研究所, 脳神経科学研究センター, 副チームリーダー (90608530)
• Project Period (FY): 2018-06-29 – 2021-03-31
• Keywords: in vivo カルシウムイメージング / 運動学習 / アデノ随伴ウイルス

Outline of Final Research Achievements

Our goal is to reveal the neuronal mechanism of motor learning using the methods to express genes in particular neuronal pathways. We investigated infection patterns of several types of adeno-associated viruses (AAV) in rodent and primate brains. We revealed that AAV exhibited anterograde transsynaptic spread properties. In the future, we would like to reveal the neuronal mechanism of motor learning using pathway-specific manners through their neuronal tropisms and infection patterns.

Free Research Field

神経科学

Academic Significance and Societal Importance of the Research Achievements

我々は、げっ歯類および霊長類の脳に経路特異的に遺伝子発現させる方法を開発した。この方法を用いて、様々な精神・疾患モデルの脳に蛍光カルシウムセンサーを発現させて、顕微鏡下で脳の活動を計測することによって、疾患における神経ネットワーク変容の理解に役立てることが期待できる。