Development of Novel Boration Reactions based on Design and Control of Transition States

2020 Fiscal Year Final Research Report

• Project/Area Number: 18K19390
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 47:Pharmaceutical sciences and related fields
• Research Institution: The University of Tokyo
• Principal Investigator: HIRANO Keiichi 東京大学, 大学院薬学系研究科(薬学部), 特任准教授 (40633392)
• Project Period (FY): 2018-06-29 – 2021-03-31
• Keywords: ホウ素 / ケイ素 / 遷移状態 / ヘテロ元素 / π 共役系

Outline of Final Research Achievements

Boron has been attracting much attention in the field of materials science and medicinal chemistry since it can form stable chemical bondings with carbon. I have worked on the studies focusing on boron-introducing methodologies to conjugated π-electron systems, that are the most important and fundamental chemical units in the above mentioned research fields. Theoretical chemistry-assisted minute designs of transition states of the targeted boration reactions enabled the synthesis of unprecedented boron-containing extended stilbene and 1-boraphenalenes. A novel hydrosilylation methodology leading to the formation of functionalized sila-aromatics was also discovered relatedly.

Free Research Field

有機合成化学

Academic Significance and Societal Importance of the Research Achievements

これまでの機能性材料や医薬分子は炭素、酸素、水素、窒素をはじめとする基本的な元素で構築されてきたが、周期表横断型-縦断型の元素化学は多種多様の元素同士の無限の組み合わせにより、これまでにない機能をもたらすことができると考えられる。今回、本研究支援を基に申請者らは旧来の「求電子的」な手法に対し、「求核的」なアプローチにて芳香環をはじめとする π 共役系分子へのホウ素およびケイ素導入反応を開発し、従来法では合成することができなかった様々な骨格構築に成功した。こうして拓いた新しい化学空間は、新しい機能性材料や医薬品の探索研究に大きく貢献していくものと考えられる。