2021 Fiscal Year Final Research Report
New nanoparticle for neurodiagnosis of "diagnosing pain"
| Project/Area Number |
18K19413
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 47:Pharmaceutical sciences and related fields
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| Research Institution | Showa University |
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Principal Investigator |
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| Project Period (FY) |
2018-06-29 – 2022-03-31
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| Keywords | 分析科学 / ナノ粒子 / DDS |
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| Outline of Final Research Achievements |
In this study, using the mesh structure of nanogel, a complex containing heavy metals is used as a contrast agent in a state of being isolated and protected from the in-vivo environment, and the contrast medium is quickly and surely used in a safe form from the in-vivo.
With a two-step approach of excretion, we actually made a prototype of nanogel with reduced toxicity with the aim of developing a low-toxicity renal excretory nanogel neurodiagnosis probe platform and evaluating pain using it. In fact, we succeeded in minimally invasive imaging of rat nerves.
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| Free Research Field |
分析化学
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| Academic Significance and Societal Importance of the Research Achievements |
現在、病院などのMRIで生体内部を観察するために用いられている薬は、重金属由来のものであり、毒性の高い物が用いられている。高齢化社会が進む近い将来、大きな問題になる慢性疼痛について、観察する手段としてそのような薬を繰り返し用いると、歩行できなくなる位の酷い腫れなどが起こるとラットでの実験結果から予想され、用いることは好ましくないが、ナノ粒子を用いて改良することで、そのような問題が解決できる。
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