Development of a tri-functional chelate for nuclear/fluorescence dual imaging

2019 Fiscal Year Final Research Report

• Project/Area Number: 18K19527
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 52:General internal medicine and related fields
• Research Institution: Kobe Pharmaceutical University
• Principal Investigator: Mukai Takahiro 神戸薬科大学, 薬学部, 教授 (30284706)
• Project Period (FY): 2018-06-29 – 2020-03-31
• Keywords: 放射性医薬品 / イメージング / ガリウム / 蛍光 / 薬学

Outline of Final Research Achievements

The imaging probes applicable to both nuclear medical imaging and fluorescence imaging could provide identical information for both pre- and intra-operative diagnoses of cancers, leading to precise surgical therapy. In this study, since two free carboxylate groups of the radiogallium-DOTA complex could be used for coupling to functional moieties that recognize cancer-specific molecular targets, we introduced a fluorescence dye to a carboxylate group on DOTA, and furthermore, a folate derivative to an another carboxylate group. The new compound could detect ovarian cancers highly expressing folate receptors in vivo.

Free Research Field

放射線科学

Academic Significance and Societal Importance of the Research Achievements

核医学診断と蛍光イメージングを同時に達成しうる薬剤骨格を開発できれば、がんの診断から治療への効率的ワークフローを構築でき、高効率な確定診断と、それに基づく効果的な治療法の迅速な選択・決定が可能になると考えられる。それにより、がんの早期における治療戦略決定が可能となり、最適な治療法選択と実施推進により治療効果の向上、必要な治療法の絞込みによる医療経済効果への寄与が期待できる。