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2022 Fiscal Year Final Research Report

Development of bioluminescent sensors and their application to breast cancer cells

Research Project

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Project/Area Number 18K19573
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
Research InstitutionThe University of Tokyo

Principal Investigator

Noda Natsumi  東京大学, 大学院理学系研究科(理学部), 特任研究員 (30624358)

Project Period (FY) 2018-06-29 – 2023-03-31
Keywords乳癌 / CD44 / 生物発光 / ルシフェラーゼ / 癌幹細胞 / 浸潤
Outline of Final Research Achievements

This study aimed to develop new therapy for breast cancer. We focused on CD44, a marker for breast cancer stem cells. CD44 undergoes ectodomain cleavage by membrane-associated metalloproteinases in breast cancer cells. Cleavage plays a critical role in cancer cell migration. To explore inhibitors of CD44 ectodomain cleavage, we developed bioluminescent sensors. The sensors revealed that a drug suppressed the invasion of breast cancer cells.

Free Research Field

乳癌

Academic Significance and Societal Importance of the Research Achievements

現在, 日本において乳癌は40代女性の癌部位別死亡率1位である. トリプルネガティブ(エストロゲン受容体, プロゲステロン受容体, 及びHER2発現陰性)乳癌は, 骨や中枢神経系への転移が多く再発率が高いことから, より優れた治療法の開発が急務である. このような有効な治療法が確立できていない難治性癌に対し, 癌幹細胞を標的とした治療法を開発し, 癌の根治や長期延命を実現したいと考えた. 本研究は, 乳癌幹細胞マーカーであるCD44を標的とした発光センサーを開発し, 乳癌細胞の浸潤を抑制する薬剤を見出すことに成功したことで, 乳癌治療の新たな選択肢となる可能性を示した.

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Published: 2024-01-30  

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