Identify suppressors of sarcoma initiation with newly established uterine sarcoma mouse model to develop novel molecular targeted therapy

2019 Fiscal Year Final Research Report

• Project/Area Number: 18K19607
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
• Research Institution: Kanazawa University
• Principal Investigator: Daikoku Takiko 金沢大学, 学際科学実験センター, 教授 (30767249)
• Co-Investigator(Kenkyū-buntansha): 藤原 浩 金沢大学, 医学系, 教授 (30252456) ; 中村 充宏 金沢大学, 医学系, 講師 (50377397)
• Project Period (FY): 2018-06-29 – 2020-03-31
• Keywords: 子宮肉腫 / マウスモデル

Outline of Final Research Achievements

We previously established a novel uterine sarcoma mouse model by long-term treatment of progesterone to uterine specific Pten null mice. In this research, we found that normal Pten in uterine epithelium is essential to repress initiation of uterine stromal sarcoma in mouse. We also found some candidates which plays important role for initiation of uterine stromal sarcoma.

Free Research Field

婦人科腫瘍

Academic Significance and Societal Importance of the Research Achievements

本研究で得られた子宮間質肉腫発生に上皮細胞の作用が影響するという結果は新しい知見であり、学術的意義がある。また、本研究で新たに発見された子宮間質肉腫発生に関わると考えられる因子は、子宮肉腫の新たな治療ターゲットとなり、新規治療薬の開発につながると考えられ、社会的意義がある。