2022 Fiscal Year Final Research Report

Novel serum diagnosis of brain tumors by NMR analysis based on mode analysis

Research Project

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Project/Area Number	18K19623
Research Category	Grant-in-Aid for Challenging Research (Exploratory)
Allocation Type	Multi-year Fund
Review Section	Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
Research Institution	Nippon Medical School
Principal Investigator	Adachi Koji 日本医科大学, 医学部, 准教授 (00231928)
Co-Investigator(Kenkyū-buntansha)	小池薫京都大学, 医学研究科, 名誉教授 (10267164) 平川慶子日本医科大学, 医学部, 非常勤講師 (30165162) 柚木知之京都大学, 医学研究科, 准教授 (50639094) 金涌佳雅日本医科大学, 大学院医学研究科, 大学院教授 (80465343)
Project Period (FY)	2018-06-29 – 2023-03-31
Keywords	脳腫瘍 / メタボロミクス / モード解析 / 血清診断
Outline of Final Research Achievements	There are may types of brain tumors, and some of them are difficult to distinguish from other disease, so it is often difficult to dianose them using neuroimaging alone. We wanted to see if a single serology test could determine whether a patient had a brain tumor, a glial tumor or not. <method> NMR mode analysis was performed using serum collected from patients with brain tumors including gliomas and non-neoplastic brain diseases. <results> This diagnostic method clearly divided into three groups: gliomas, non-gliomatous brain tumors, and non-neoplastic brain diseases. It was suggested that this diagnostic method may be useful for determining the presence or absence of brain tumors and identifying their types.
Free Research Field	脳腫瘍学
Academic Significance and Societal Importance of the Research Achievements	NMR メタボロミクスは液体に含まれる複数の物質を同時かつ網羅的に化学分析する手法であるが、NMR モード解析は、メタボロミクスとは異なり、液体の動的性質を NMR モードという物理量で評価する。このモード解析は、僅か 0.1mL の血清の1回の NMR 実測値から多くの臨床情報を引き出せる点が画期的である。本技術を脳腫瘍に応用すると、脳腫瘍のスクリーニング、早期診断、治療方針の決定、治療効果の判定、予後予測に有用である可能性がある。