2019 Fiscal Year Final Research Report

Molecular mechanisms of p75NTR modulation in the regeneration of pulp sensory function

Research Project

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Project/Area Number	18K19632
Research Category	Grant-in-Aid for Challenging Research (Exploratory)
Allocation Type	Multi-year Fund
Review Section	Medium-sized Section 57:Oral science and related fields
Research Institution	Tohoku University
Principal Investigator	Inuzuka Hiroyuki 東北大学, 歯学研究科, 准教授 (20335863)
Co-Investigator(Kenkyū-buntansha)	福本敏九州大学, 歯学研究院, 教授 (30264253) 齋藤正寛東北大学, 歯学研究科, 教授 (40215562) 清水康平大阪市立大学, 大学院医学研究科, 助教 (70727073)
Project Period (FY)	2018-06-29 – 2020-03-31
Keywords	p75NTR
Outline of Final Research Achievements	Efficient regeneration of pulp sensory function requires neural and axon regeneration and proper axon guidance in the dental pulp. In this study, we focused on the regulatory mechanisms of p75 neurotrophin receptor (p75NTR), an essential factor for neural differentiation, survival, and axon elongation. We found that post-translational modifications play a role in the regulation of p75NTR and modulate its activity. The findings of this study will provide an insight into developing a potential approach for the efficient regeneration of pulp function.
Free Research Field	分子生物学
Academic Significance and Societal Importance of the Research Achievements	間葉系幹細胞マーカーおよび神経成長因子受容体として機能するp75NTRの活性調節分子機序を解析し受容体活性化の任意制御を試みることは、効率的な神経分化誘導法の開発に向けた有力なアプローチとなり得る。移植医療分野で応用が進む間葉系幹細胞移植は特に脊髄損傷や脳梗塞など神経変性疾患の分野で顕著な成績を上げていることから、本研究で得られた知見は、神経組織・知覚機能再生法開発の分子機序解明の手がかりとなる可能性を有している。