2023 Fiscal Year Final Research Report

Are differences in the capacity to oxidize fat associated with the risk of developing lifestyle-related diseases in middle-aged and older adults?

Research Project

PDF

Project/Area Number	18K19759
Research Category	Grant-in-Aid for Challenging Research (Exploratory)
Allocation Type	Multi-year Fund
Review Section	Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
Research Institution	Surugadai University (2021-2023) Waseda University (2018-2020)
Principal Investigator	Sakamoto Shizuo 駿河台大学, スポーツ科学部, 特任教授 (00266032)
Co-Investigator(Kenkyū-buntansha)	谷澤薫平早稲田大学, スポーツ科学学術院, 准教授 (50771812) 田端宏樹順天堂大学, 大学院医学研究科, 博士研究員 (50876886)
Project Period (FY)	2018-06-29 – 2024-03-31
Keywords	脂質代謝能力 / 生活習慣病 / 遺伝因子 / メタボリックシンドローム
Outline of Final Research Achievements	The capacity to oxidize fat refers to the ability to utilize lipids as an energy substrate within the body. Although a decline in the capacity to oxidize fat has been reported to be associated with weight gain and insulin resistance, its direct relationship with lifestyle-related diseases remains unclear. Therefore, we examined the association between the capacity to oxidize fat and lifestyle-related diseases in a cohort of middle-aged and elderly Japanese men and women. Our study results indicated that, particularly among men with visceral fat obesity, there is a potential association between the capacity to oxidize fat and lipid metabolism disorders. Furthermore, longitudinal research suggested that changes in the capacity to oxidize fat may be linked to the onset of hypertension. Moving forward, we plan to continue follow-up studies on the cohort to more precisely investigate the relationship between changes in the capacity to oxidize fat and the onset of lifestyle-related diseases.
Free Research Field	スポーツ医学
Academic Significance and Societal Importance of the Research Achievements	脂質代謝能力の低下はインスリン抵抗性の増大やメタボリックシンドローム危険因子保有数と関連すると示されていたが、本研究で初めて、男性内臓脂肪型肥満者と限定的ではあるものの、生活習慣病と関連する可能性が示唆された。内臓脂肪型肥満者で関連がみられた点より、脂質代謝能力はメタボリックシンドロームから生活習慣病発症までの過程でのリスク評価や予防介入指標として役立つ可能性があるかもしれない。