Mechano- and chem-gradient gel for novel scaffold using in tissue repair

2020 Fiscal Year Final Research Report

• Project/Area Number: 18K19907
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 90:Biomedical engineering and related fields
• Research Institution: University of Toyama
• Principal Investigator: Nakaji-Hirabayashi Tadashi 富山大学, 学術研究部工学系, 准教授 (10543217)
• Co-Investigator(Kenkyū-buntansha): 松村 和明 北陸先端科学技術大学院大学, 先端科学技術研究科, 教授 (00432328)
• Project Period (FY): 2018-06-29 – 2021-03-31
• Keywords: メカノケミグラジエントゲル / 軟骨再生 / 傾斜階層構造 / 人工組織体 / 高分子ゲル

Outline of Final Research Achievements

The key point on the research is the construction of gel material for chondrocytes tissue having the hierarchical structure. In the research, we could develop the mechano-gradient gel to work as trigger for constructing the chondrocytes tissue having the hierarchical structure. Although this gel material need the improvement and optimization for effective differentiation from hMSCs to chondrocytes, we got the important and great achievement for the in vitro construction of the artificial cartilage.

Free Research Field

再生医工学

Academic Significance and Societal Importance of the Research Achievements

本研究課題は，変性軟骨疾患の再生医療の発展に貢献する可能性を秘めた萌芽的研究であり，社会的意義が非常に大きな研究であることはもちろんのこと，高分子ゲルと細胞を組み合わせて，生体組織にできる限り近づけた人工組織を，生体外で構築できる方法の提案につながる可能性を秘めており，再生医学・バイオマテリアル工学の発展にとっても非常に意義のある研究課題といえる。