Pathophysiology analysis and clinical application development of cartilage degenerative diseases based on label-free imaging technology

2020 Fiscal Year Final Research Report

• Project/Area Number: 18K19927
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 90:Biomedical engineering and related fields
• Research Institution: Ehime University
• Principal Investigator: Kiyomatsu Hiroshi 愛媛大学, 医学部附属病院, 助教(病院教員) (80756362)
• Co-Investigator(Kenkyū-buntansha): 大嶋 佑介 大分大学, 医学部, 客員研究員 (10586639)
• Project Period (FY): 2018-06-29 – 2021-03-31
• Keywords: 変形性関節症 / 軟骨 / バイオイメージング / ラマン分光法 / 第２次高調波 / 軟骨再生 / 軟骨変性

Outline of Final Research Achievements

A treatment method for regenerating and repairing degenerative cartilage in osteoarthritis has not been established, and there is no technique for identifying pathological changes of degenerative cartilage at an extremely early phase. In this study, we succeeded in identifying changes in the molecular composition of the extra-cellular matrix of cartilage by performing Raman spectroscopic analysis on the specimens removed in total knee replacement.
We also create a prototype of the device to be mounted on an arthroscope for surgery, based on that system. We plan to apply these devices clinically in the future.

Free Research Field

整形外科分野

Academic Significance and Societal Importance of the Research Achievements

これらの技術が完成することにより、これまで捉えることのできなかった、軟骨変性の質的評価が可能になり、また未だ確立されていない軟骨再生医療の発展と
軟骨再生の過程を評価に寄与することができる。