2010 Fiscal Year Final Research Report
Chemical Syntheses of Natural and Designed Molecules : Innovative Research on Their New Functions, Antibodies and Receptors
| Project/Area Number |
19001003
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| Research Category |
Grant-in-Aid for Specially Promoted Research
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| Allocation Type | Single-year Grants |
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| Review Section |
Science and Engineering
Chemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FUJII Ikuo 大阪府立大学, 大学院・理学研究科, 教授 (70189984)
YAMASHITA Syuuji 東北大学, 大学院・理学研究科, 助教 (50419991)
YAMAOKA Kaoru 広島国際大学, 保健医療学部, 教授 (10200586)
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| Co-Investigator(Renkei-kenkyūsha) |
TSUMURAYA Takeshi 大阪府立大学, 大学院・理学研究科, 准教授 (00372855)
SATO Itaru 東北大学, 大学院・理学研究科, 准教授 (80318196)
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| Project Period (FY) |
2007 – 2010
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| Keywords | 全合成 / シガトキシン / モノクローナル抗体 / ELISA / チャネル / エンジイン |
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| Research Abstract |
We have developed a general method for the total syntheses of ciguatoxins. Practical total synthesis of ciguatoxins allowed us to use them for interdisciplinary researches, such as unveiling the gating mechanism of voltage sensitive sodium channels. Highly sensitive anti-CTXlB monoclonal antibodiy and immunoassay method were developed to detect major congeners of ciguatoxin. Some of the previously prepared antibodies were modified for treating the human ciguatera poisoning. Furthermore, designed pseudo-ciguatoxins were also synthesized as bio-probes for understanding the biological mechanisms. On the other hand, total syntheses of the extremely potent antitumor chromoprotein nine-membered enediyne antibiotics and cortistatins were accomplished.
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Research Products
(60 results)
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[Journal Article] Critical Contribution of Aromatic Rings to Specific Recognition of Polyether Rings:The Case of Ciguatoxin CTX3C-ABC and Its Specific Antibody 1C492008
Author(s)
K. Tsumoto, A. Yokota, Y. Tanaka, M. Ui, T. Tsumuraya, I. Fujii, I. Kumagai, Y. Nagumo, H. Oguri, M. Inoue, and M. Hirama
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Journal Title
J. Biol. Chem.
Volume: 283
Pages: 12259-12266
Peer Reviewed
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