Dynamical mechanisms underlying cognitive memory in primates : Functional analysis its global network and local circuit

2009 Fiscal Year Self-evaluation Report

• Project/Area Number: 19002010
• Research Category: Grant-in-Aid for Specially Promoted Research
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: The University of Tokyo
• Principal Investigator: MIYASHITA Yasushi The University of Tokyo, 大学院・医学系研究科, 教授 (40114673)
• Project Period (FY): 2007 – 2011
• Keywords: 神経科学 / 大脳皮質 / 記憶 / 電気生理 / 磁気共鳴機能画像

Research Abstract

記憶の神経科学研究は、過去10年間に飛躍的な進歩を遂げた。しかし、機能的・情報的観点から脳全体の大域的活動の巨視的知見とシナプス可塑性についての微視的知見を統合し、大脳神経ネットワークの時間軸に沿った動的な情報処理過程を解明する道程はまだ遠い。このダイナミクス解明の為に、脳全体に散在する多数の情報処理ユニット間でどのような情報が交換されるか、これら情報処理ユニット内部の局所神経回路でこの情報がいかに変換・生成されているか、との問いに答えることを目的とする。

Research Products

• [Journal Article] Cognitive set reconfiguration signaled by macaque posterior parietal neurons. (2009)
  • Author(s): Kamigaki, T., Fukushima, T., Miyashita, Y.
  • Journal Title: Neuron 61 Pages: 941-951
  • Peer Reviewed
• [Journal Article] Preparation to inhibit a response complements response inhibition during performance of a stop-signal task. (2009)
  • Author(s): Chikazoe, J., Jimura, K., Hirose, S., Yamashita, K-I., Miyashita, Y., Konishi, S.
  • Journal Title: J. Neurosci. 29 Pages: 15870-15877
  • Peer Reviewed
• [Journal Article] Formation of Long-Term Memory Representation in Human Temporal Cortex Related to Pictorial Paired Associates. (2009)
  • Author(s): Yamashita, K., Hirose, S., Kunimatsu, A., Aoki, S., Chikazoe, J., Jimura, K., Masutani, Y., Abe, O., Ohtomo, K., Miyashita, Y., Konishi, S.
  • Journal Title: J. Neurosci. 29 Pages: 10335-10340
  • Peer Reviewed
• [Journal Article] MRI-based localization of electrophysiological recording sites within the cerebral cortex at single voxel accuracy. (2007)
  • Author(s): Matsui, T., Koyano, K.W., Koyama, M., Nakahara, K., Takeda, M., Ohashi, Y., Naya, Y., Miyashita, Y.
  • Journal Title: Nature methods 4 Pages: 161-168
  • Peer Reviewed
• [Presentation] Transneuronal circuit tracing of the rat cerebellar pathways with a bicistronic lentiviral vector co-expressing green fluorescent protein and wheat germ agglutinin. (2009)
  • Author(s): Ohashi, Y., Tsubota, T., Sato, A., Koyano, K.W., Tamura, K., Miyashita, Y.
  • Organizer: 第39回北米神経科学学会
  • Place of Presentation: シカゴ, 米国
  • Year and Date: 2009-10-19
• [Presentation] Neuronal representation of stimulusstimulus associations in area 35 of macaque perirhinal cortex. (2009)
  • Author(s): Fujimichi, R, Takeda, M., Koyano, K.W., Naya, Y., Takeuchi, D., Miyashita, Y.
  • Organizer: 第39回北米神経科学学会
  • Place of Presentation: シカゴ, 米国
  • Year and Date: 2009-10-17
• [Presentation] Electrolysis of an elgiloy electrode can create MRI-visible metal deposit marks at recording sites. (2008)
  • Author(s): Koyano, K.W., Machino, A., Takeda, M., Fujimichi, R., Ohashi, Y., Matsui, T., Miyashita, Y.
  • Organizer: 第38回北米神経科学学会
  • Place of Presentation: ワシントンD.C., 米国
  • Year and Date: 2008-11-19