Dynamical mechanisms underlying cognitive memory in primates : Functional analysis of its global network and local circuit

2011 Fiscal Year Final Research Report

• Project/Area Number: 19002010
• Research Category: Grant-in-Aid for Specially Promoted Research
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: The University of Tokyo
• Principal Investigator: MIYASHITA Yasushi 東京大学, 大学院・医学系研究科, 教授 (40114673)
• Project Period (FY): 2007 – 2011
• Keywords: 神経科学 / 大脳皮質 / 記憶 / 電気生理 / 磁気共鳴機能画像

Research Abstract

We analyzed the neural mechanisms underlying cognitive memory from two view-points : one is a local circuit(or processing unit) that generates and transforms encoding/recall signals, and the other is a global cortical network in which local processing units exchange bottom-up or top-down search signals. We identified many functional global networks using effective connectivity measures in BOLD fMRI. We also found a flexible recruitment of interlaminar connectivity in the local circuit of six-layered association cortices, depending on the cognitive demand. Our study provided a breakthrough in understanding of the operation principles of the primate cerebral cortex for cognitive memory.

Research Products

• [Journal Article] Functional Dissociation between Anterior and Posterior Temporal Cortical Regions during Retrieval of Remote Memory (2012)
  • Author(s): Watanabe, T., Kimura, H. M., Hirose, S., Wada, H., Imai, Y., Machida, T., Shirouzu, I., Miyashita, Y. and Konishi, K.
  • Journal Title: J. Neurosci Volume: (掲載確定)
• [Journal Article] Optogenetic inhibition of Purkinje cell activity reveals cerebellar control of blood pressure during postural alterations in anesthetized rats (2012)
  • Author(s): Tsubota, T., Ohashi, Y., Tamura, K. and Miyashita, Y.
  • Journal Title: Neuroscience
  • DOI: DOI:10.1016/j.neuroscience.2012.03.014
• [Journal Article] Efficiency of Go/No-Go Task Performance Implemented in the Left Hemisphere (2012)
  • Author(s): Hirose, S., Chikazoe, J., Watanabe, T., Jimura, K., Kunimatsu, A., Abe, O., Ohtomo, K., Miyashita, Y. and Konishi, S.
  • Journal Title: J. Neurosci Volume: (掲載確定)
• [Journal Article] Functional Connectivity between Anatomically Unconnected Areas Is Shaped by Collective Network-level Effects in the Macaque Cortex (2012)
  • Author(s): Adachi, Y., Osada, T., Sporns, O., Watanabe, T., Matsui, T., Miyamoto, K. and Miyashita, Y.
  • Journal Title: Cereb. Cortex
  • DOI: DOI:10.1093/cercor/bhr234
• [Journal Article] Reversal of interlaminar signal between sensory and memory processing in monkey temporal cortex (2011)
  • Author(s): Takeuchi, D., Hirabayashi, T., Tamura, K. and Miyashita, Y.
  • Journal Title: Science Volume: 331 Pages: 1443-1447
  • DOI: DOI:10.1126/science.1199967
• [Journal Article] In vivo visualization of single-unit recording sites using MRI-detectable elgiloy deposit marking (2011)
  • Author(s): Koyano, K. W., Machino, A., Takeda, M., Matsui, T., Fujimichi, R., Ohashi, Y. and Miyashita, Y.
  • Journal Title: J. Neurophysiol Volume: 105 Pages: 1380-1392
  • DOI: DOI:10.1152/jn.00358.2010
• [Journal Article] Neuronal signal dynamics during preparation and execution for behavioral shifting in Macaque posterior parietal cortex (2011)
  • Author(s): Kamigaki, T., Fukushima, T. and Miyashita, Y.
  • Journal Title: J. Cogn. Neurosci Volume: 23 Pages: 2503-2520
  • DOI: DOI:10.1162/jocn.2011.21613
• [Journal Article] Direct comparison of spontaneous functional connectivity and effective connectivity measured by intracortical microstimulation : an fMRI study in macaque monkeys (2011)
  • Author(s): Matsui, T., Tamura, K., Koyano, K. W., Takeuchi, D., Adachi, Y., Osada, T. and Miyashita, Y.
  • Journal Title: Cereb. Cortex Volume: 21 Pages: 2348-2356
  • DOI: DOI:10.1093/cercor/bhr019
• [Journal Article] Role for presupplementary motor area in inhibition of cognitive set interference (2011)
  • Author(s): Konishi, S., Watanabe, T., Jimura, K., Chikazoe, J., Hirose, S., Kimura, H. M. and Miyashita, Y.
  • Journal Title: J. Cogn. Neurosci Volume: 23 Pages: 737-745
  • DOI: DOI:10.1162/jocn.2010.21480
• [Journal Article] A bicistronic lentiviral vector-based method for differential transsynaptic tracing of neural circuits (2011)
  • Author(s): Ohashi, Y., Tsubota, T., Sato, A., Koyano, K. W., Tamura, K. and Miyashita, Y.
  • Journal Title: Mol. Cell. Neurosci Volume: 46 Pages: 136-147
  • DOI: DOI:10.1016/j.mcn.2010.08.013
• [Journal Article] Optogenetic manipulation of cerebellar Purkinje cell activity in vivo (2011)
  • Author(s): Tsubota, T., Ohashi, Y., Tamura, K., Sato, A., and Miyashita, Y.
  • Journal Title: PLoS One Volume: 6 Pages: 22400
  • DOI: DOI:10.1371/journal.pone.0022400
• [Journal Article] Triphasic dynamics of stimulus-dependent information flow between single neurons in macaque inferior temporal cortex (2010)
  • Author(s): Hirabayashi, T., Takeuchi, D., Tamura, T. and Miyashita, Y.
  • Journal Title: J. Neurosci Volume: 30 Pages: 10407-10421
  • DOI: DOI:10.1523/JNEUROSCI.0135-10.2010
• [Journal Article] Amygdalar modulation of frontotemporal connectivity during the inkblot test (2010)
  • Author(s): Asari, T., Konishi, S., Jimura, K., Chikazoe, J., Nakamura, N. and Miyashita, Y.
  • Journal Title: Psychiatry Research : Neuroimaging Volume: 182 Pages: 103-110
  • DOI: DOI:10.1016/j.pscychresns.2010.01.002
• [Journal Article] Amygdalar enlargement associated with unique perception (2010)
  • Author(s): Asari, T., Konishi, S., Jimura, K., Chikazoe, J., Nakamura, N. and Miyashita, Y.
  • Journal Title: Cortex Volume: 46 Pages: 94-99
  • DOI: DOI:10.1016/j.cortex.2008.08.001
• [Journal Article] Cognitive set reconfiguration signaled by macaque posterior parietal neurons (2009)
  • Author(s): Kamigaki, T., Fukushima, T., and Miyashita, Y.
  • Journal Title: Neuron Volume: 61 Pages: 941-951
  • DOI: DOI:10.1016/j.neuron.2009.01.028
• [Journal Article] Preparation to inhibit a response complements response inhibition during performance of a stop-signal task (2009)
  • Author(s): Chikazoe, J., Jimura, K., Hirose, S., Yamashita, K-I., Miyashita, Y. and Konishi, S.
  • Journal Title: J. Neurosci Volume: 29 Pages: 15870-15877
  • DOI: DOI:10.1523/JNEUROSCI.3645-09.2009
• [Journal Article] Formation of long-term memory representation in human temporal cortex related to pictorial paired associates (2009)
  • Author(s): Yamashita, K., Hirose, S., Kunimatsu, A., Aoki, S., Chikazoe, J., Jimura, K., Masutani, Y., Abe, O., Ohtomo, K., Miyashita, Y. and Konishi, S.
  • Journal Title: J. Neurosci Volume: 29 Pages: 10335-10340
  • DOI: DOI:10.1523/JNEUROSCI.1328-09.2009
• [Journal Article] Functional dissociation in right inferior frontal cortex during performance of go/no-go task (2009)
  • Author(s): Chikazoe, J., Jimura. K., Asari, T., Yamashita, K., Morimoto, H., Hirose, S., Miyashita, Y. and Konishi, S.
  • Journal Title: Cereb. Cortex Volume: 19 Pages: 146-152
  • DOI: DOI:10.1093/cercor/bhn065
• [Journal Article] Toward understanding of the cortical network underlying associative memory (2008)
  • Author(s): Osada, T., Adachi, Y., Kimura, H. M. and Miyashita, Y.
  • Journal Title: Philos. Trans. R. Soc. Lond., B, Biol. Sci Volume: 363 Pages: 2187-2199
  • DOI: DOI:10.1098/rstb.2008.2271
• [Journal Article] On verbal/nonverbal modality dependence of left and right inferior prefrontal activation during performance flanker interference task (2008)
  • Author(s): Morimoto, H. M., Hirose, S., Chikazoe, J., Jimura, K., Asari, T., Yamashita, K., Miyashita. Y. and Konishi, S.
  • Journal Title: J. Cogn. Neurosci Volume: 20 Pages: 2006-2014
  • DOI: DOI:10.1162/jocn.2008.20138
• [Journal Article] Right temporopolar activation associated with unique perception (2008)
  • Author(s): Asari, T., Konishi, S., Jimura, K., Chikazoe, J., Nakamura, N. and Miyashita, Y.
  • Journal Title: NeuroImage Volume: 41 Pages: 145-152
  • DOI: DOI:10.1016/j.neuroimage.2008.01.059
• [Journal Article] MRI-based localization of electrophysiological recording sites within the cerebral cortex at single voxel accuracy (2007)
  • Author(s): Matsui, T., Koyano, K. W., Koyama, M., Nakahara, K., Takeda, M., Ohashi, Y., Naya, Y. and Miyashita, Y.
  • Journal Title: Nature methods Volume: 4 Pages: 161-168
  • DOI: DOI:10.1038/nmeth987
• [Journal Article] Exploring the neural basis of cognition : multi-modal links between human fMRI and macaque neurophysiology (2007)
  • Author(s): Nakahara, K., Adachi, Y., Osada, T. and Miyashita Y.
  • Journal Title: Trend Cogn. Science Volume: 11 Pages: 84-92
  • DOI: DOI:10.1016/j.tics.2006.11.006
• [Journal Article] Activation of right inferior frontal gyrus during response inhibition across response modalities (2007)
  • Author(s): Chikazoe, J., Konishi, S., Asari, T., Jimura, K. and Miyashita, Y.
  • Journal Title: J. Cogn. Neurosci Volume: 19 Pages: 69-80
  • DOI: DOI:10.1162/jocn.2007.19.1.69
• [Presentation] Neuroscience and Higher Brain Function : State of the Art (2012)
  • Organizer: The Neuroscience Institute, Fiftieth Anniversary Celebration
  • Place of Presentation: San Diego, U. S. A.
  • Year and Date: 20120415-17
• [Presentation] The Frontiers of Knowledge (2011)
  • Organizer: Todai Forum 2011 "Aux frontieres de la connaissance"
  • Place of Presentation: Paris, France
  • Year and Date: 20111017-19
• [Presentation] Oxford McDonnell Network for Cognitive Neuroscience (2011)
  • Organizer: A symposium in honour of David Gaffan
  • Place of Presentation: Oxford, United Kingdom
  • Year and Date: 20110926-29
• [Presentation] The Annual Lecture in Computational Neuroscience in Memory of the late Professor Daniel Amit (2009)
  • Place of Presentation: Jerusalem, Israel
  • Year and Date: 2009-12-10
• [Presentation] Cognitive memory system : brain-wide networks and local circuits (2008)
  • Organizer: The 31st Annual Meeting of Japan Neuroscience Society, Plenary Lecture
  • Place of Presentation: Tokyo
  • Year and Date: 20080709-11
• [Presentation] Memory and Cognitive Control in the Primate (2008)
  • Organizer: The 44th Meeting of the US-Japan Cooperative Medical "Science Imaging and Medicine in the 21st Century"
  • Place of Presentation: Minneapolis, U. S. A.
  • Year and Date: 20080615-16
• [Presentation] Memory circuit in the primate : Global and local (2008)
  • Organizer: Fridtj of Nansen conference on Neural Networks and Behaviour
  • Place of Presentation: Svalbard, Norway
  • Year and Date: 20080604-07
• [Remarks]
  • URL: http://www.physiol.m.u-tokyo.ac.jp/