Phospholipid metabolism and lipid mediators

2009 Fiscal Year Self-evaluation Report

• Project/Area Number: 19002011
• Research Category: Grant-in-Aid for Specially Promoted Research
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: The University of Tokyo
• Principal Investigator: SHIMIZU Takao The University of Tokyo, 大学院・医学系研究科, 教授 (80127092)
• Project Period (FY): 2007 – 2011
• Keywords: 脂質メディエーター / ロイコトリエン / アシル転移酵素 / ホスホリパーゼA2 / 遺伝子欠損マウス / G タンパク共役型受容体 / 脂質メタボローム / 肺サーファクタント

Research Abstract

(1) 膜リン脂質代謝の解析(ホスホリパーゼA2およびアシル転移酵素ファミリー遺伝子の同定と機能解析)
(2) 脂質メディエーターの生理的意義、病態における役割とその分子機構の解明
(3) 脂質メディエーターの網羅的、且つ定量的な解析システムとデータベースの作成

Research Products

• [Journal Article] Prostaglandin F2α receptor signaling facilitates bleomycin-induced pulmonary fibrosis independently of transforming growth factor-β. (2009)
  • Author(s): Oga, T., Matsuoka, T., Yao, C., Nonomura, K., Kitaoka, S., Sakata, D., Kita, Y., Tanizawa, K., Taguchi, Y., Chin, K., Mishima, M., Shimizu, T., Narumiya, S.
  • Journal Title: Nature Med. 12 Pages: 1426-1430
  • Peer Reviewed
• [Journal Article] Targeted lipidomics reveals mPGES-1-PGE2 as a therapeutic target for multiple sclerosis. (2009)
  • Author(s): Kihara, Y., Matsushita, T., Kita, Y., Uematsu, S., Akira, S., Kira, J.-i., Ishii, S., Shimizu, T.
  • Journal Title: Proc. Natl. Acad. Sci. U.S.A. 106 Pages: 21807-21812
  • Peer Reviewed
• [Journal Article] A distinctive role of the leukotriene B4 receptor BLT1 in osteoclastic activity during bone loss. (2009)
  • Author(s): Hikiji, H., Ishii, S., Yokomizo, T., Takato, T., Shimizu, T.
  • Journal Title: Proc. Natl. Acad. Sci. U.S.A. 106 Pages: 21294-21299
  • Peer Reviewed
• [Journal Article] 12(s)-Hydroxyheptadeca-5Z, 8E, 10E-trienoic acid is a natural ligand for leukotriene B4 receptor 2. (2008)
  • Author(s): Okuno, T., Iizuka, Y., Okazaki, H., Yokomizo, T., Taguchi, R., Shimizu, T.
  • Journal Title: J. Exp. Med. 205 Pages: 759-766
  • Peer Reviewed
• [Presentation] Phospholipid Metabolism: Phospholipases and Acyltransferases (2009)
  • Author(s): 清水孝雄
  • Organizer: Keystone国際学会
  • Place of Presentation: The Resort at Squaw Creek, CA, USA
  • Year and Date: 2009-04-22
• [Remarks]
  • URL: http://biochem2.umin.jp/index_j.html