Neural circuit formation in the mouse olfactory system

2009 Fiscal Year Self-evaluation Report

• Project/Area Number: 19002012
• Research Category: Grant-in-Aid for Specially Promoted Research
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: The University of Tokyo
• Principal Investigator: 坂野 仁 The University of Tokyo, 大学院・理学系研究科, 教授 (90262154)
• Project Period (FY): 2007 – 2011
• Keywords: 神経地図 / 軸索投射 / 軸索誘導分子 / シナプス形成 / 嗅神経細胞 / 匂い情報処理 / 先天的本能行動 / 記憶に基づく学習行動

Research Abstract

本研究ではマウス嗅覚系における一次神経地図の形成と二次神経とのシナプス形成の分子メカニズムの解明を行っている。更には、嗅神経回路の構成とその機能の解明を目指し、外界から入力する感覚情報が、情動や行動をどの様に発動させるかを明らかにする。

Research Products

• [Journal Article] Olfactory bulb D-V patterning is formed autonomously by olfactory neurons expressing Sema3F and Nrp2. (2010)
  • Author(s): Takeuchi, H., et al(. 12名12番目)
  • Journal Title: Cell (in press)
• [Journal Article] Neural map formation in the mouse olfactory system. (2010)
  • Author(s): Sakano, H.
  • Journal Title: Neuron (in press)
• [Journal Article] Pre-target axon sorting establishes the neural map topography. (2009)
  • Author(s): Imai, T., et al. (8名8番目)
  • Journal Title: Science 325 Pages: 585-590
• [Journal Article] RAG-heptamer interaction in the synaptic complex is a crucial biochemical checkpoint for the 12/23 recombination rule. (2008)
  • Author(s): Nishihara, T., Nagawa, F., Imai, T., Sakano, H.
  • Journal Title: J. Biol. Chem. 283 Pages: 4877-4885
• [Journal Article] Odorant receptor-mediated signaling in the mouse. (2008)
  • Author(s): Imai, T., Sakano, H.
  • Journal Title: Curr. Opin. Neurobiol. 18 Pages: 251-260
• [Journal Article] Innate versus learned odor processing in the mouse olfactory bulb. (2007)
  • Author(s): Kobayakawa, K., et al. (12名12番目)
  • Journal Title: Nature 450 Pages: 503-508
• [Journal Article] Roles of odorant receptors in projecting axons in the mouse olfactory system. (2007)
  • Author(s): Imai, T., Sakano, H.
  • Journal Title: Curr. Opin. Neurobiol. 17 Pages: 507-515
• [Journal Article] Antigen receptor genes of the agnathan lamprey are assembled by a process involving copy choice. (2007)
  • Author(s): Nagawa, F., et al. (15名15番目)
  • Journal Title: Nature Immunol. 8 Pages: 206-213
• [Journal Article] Deletion of the core-H region in mice abolishes the expression of three proximal odorant receptor genes in cis. (2007)
  • Author(s): Nishizumi, H., Kumasaka, K., Inoue, N., Nakashima, A., Sakano, H.
  • Journal Title: Proc. Natl. Acad. Sci., USA 104 Pages: 20067-20072
• [Presentation] Neural map formation in the mouse olfactory system. (2010)
  • Author(s): Hitoshi Sakano
  • Organizer: SALK-NATURE- IPSEN Symposium on Biological Complexity: Sensory Systems: Smell, Taste, Touch, Hearing and Vision.
  • Place of Presentation: Salk Institute, La Jolla, CA, USA.
  • Year and Date: 20100113-20100115
• [Presentation] Axon wiring and neural map formation in the mouse olfactory system. (2009)
  • Author(s): Hitoshi Sakano
  • Organizer: Scientific Meeting on the Chemical Senses.
  • Place of Presentation: Beijing, China
  • Year and Date: 20091115-20091117
• [Presentation] Neural map formation in the mouse olfactory system. (2009)
  • Author(s): Hitoshi Sakano
  • Organizer: EMBO Conference Series on: The Assembly and Function of Neural Circuits.
  • Place of Presentation: Monte Verita, Ascona, Switzerland.
  • Year and Date: 20091004-20091008
• [Presentation] Axon wiring and neural map formation in the mouse olfactory system. (2009)
  • Author(s): Hitoshi Sakano
  • Organizer: The XIXth ECRO Congress.
  • Place of Presentation: Sardinia, Italy.
  • Year and Date: 20090924-20090927
• [Presentation] Innate versus learned olfactory behaviors: Molecular basis of odor perception in the mouse. (2009)
  • Author(s): Hitoshi Sakano
  • Organizer: 25th Meeting of the International Society of Chemical Ecology.
  • Place of Presentation: Neuchatel, Switzerland
  • Year and Date: 20090823-20090827
• [Presentation] Molecular basis of odor perception in mouse. (2009)
  • Author(s): Hitoshi Sakano
  • Organizer: Cosmetic and Sensory Congress.
  • Place of Presentation: Vinci International Congress Centre, Tours, France
  • Year and Date: 20090624-20090626
• [Presentation] Axon wiring and neural map formation in the mouse olfactory system UCSD Seminar. (2009)
  • Author(s): Hitoshi Sakano
  • Place of Presentation: San Diego, USA
  • Year and Date: 2009-11-04
• [Presentation] Odor Perception in the Mouse Olfactory System. (2008)
  • Author(s): Hitoshi Sakano
  • Organizer: Exciting Biologies Workshop, "Biolocy of Cognition".
  • Place of Presentation: Chateau Mont Royal, Chantilly, France
  • Year and Date: 20081015-20081019
• [Presentation] Molecular basis of odor perception in the mouse. (2008)
  • Author(s): Hitoshi Sakano
  • Organizer: Seminar at The Institute for Genetics of the University of Cologne.
  • Place of Presentation: Cologne, Germany.
  • Year and Date: 2008-09-25
• [Presentation] Identity and Axonal Projection of Olfactory Sensory Neurons in the Mouse. (2007)
  • Author(s): Hitoshi Sakano
  • Organizer: International Symposium on "Olfactory information processing learning and cognition"
  • Place of Presentation: Tourtour, France
  • Year and Date: 20070827-20070901
• [Presentation] Innate versus learned odor perception in the mouse main olfactory system. (2007)
  • Author(s): Hitoshi Sakano
  • Organizer: Neurobiology Seminar, U.C. Berkeley.
  • Place of Presentation: USA. Berkeley, USA.
  • Year and Date: 2007-09-28
• [Book] Cold Spring Harbor Perspective Biology.(A. Kolodkin and M. Tessier-Lavigne Eds, Topographic Mapping-The Olfactory System) (2010)
  • Author(s): Takeshi Imai, Hitoshi Sakano, Leslie B. Vosshall
  • Publisher: Cold Spring Harbor Laboratory Press(In press)
• [Book] Chemosensory Systems in Mammals, Fishes, and Insects.(W. Meyerhof and S. Korsching Eds, Odorant Receptor Gene Choice and Axonal Projection in the Mouse Olfactory System) (2009)
  • Author(s): Takeshi Imai, Hitoshi Sakano
  • Total Pages: 57-75
  • Publisher: Springer-Verlag
• [Remarks] 新聞、テレビなどのメディア報道は国内外共に多数