Promotion of muscle activities as the countermeasure for prevention of the deterioration of brain function

2009 Fiscal Year Self-evaluation Report

• Project/Area Number: 19100009
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Sports science
• Research Institution: Osaka University
• Principal Investigator: OHIRA Yoshinobu Osaka University, 大学院・医学系研究科, 教授 (50185378)
• Project Period (FY): 2007 – 2011
• Keywords: 筋活動 / 脳機能 / 感覚神経 / プロテオミクス / 筋再生

Research Abstract

脚筋活動の程度やパターン等が脳機構に及ぼす影響を、動物およびヒトで追求する。運動が脳の機能等に影響を及ぼす機構を解明するとともに、発育抑制、損傷、老化等で退化した筋の再生助長策を解明することにより、Quality of Lifeを向上させる処方の解明に迫るため、脚活動と脳機能・タンパク質発現との関係、および筋再生処方を追求する。

Research Products

• [Journal Article] Myonucleus-related properties in soleus muscle fibers of mdx mice (2010)
  • Author(s): Terada, M., Y. B. Lan. F. Kawano, T. Ohira, Y. Higo, N. Nakai, K. Imaizumi, A. Ogura, N. Nishimoto, Y. Adachi, Y. Ohira
  • Journal Title: Cells Tissues Organs 191 Pages: 248-259
  • Peer Reviewed
• [Journal Article] Role(s) of gravitational loading during developing period on the growth of rat soleus muscle fibers (2010)
  • Author(s): Kawano F, K. Goto, X. D. Wang, M. Terada, T. Ohira, N. Nakai, T. Yoshioka, Y. Ohira
  • Journal Title: J Appl Physiol 108 Pages: 676-685
  • Peer Reviewed
• [Journal Article] Heat stress increases myonuclear number and fiber size via satellite cell activation in rat regenerating soleus fibers (2009)
  • Author(s): Oishi, Y., M. Hayashida, S. Tsukiashi, K. Taniguchi, K. Kami, R. R. Roy, Y. Ohira
  • Journal Title: J.Appl.Physiol. 107 Pages: 1612-1621
  • Peer Reviewed
• [Journal Article] Effects of peroxisome proliferator-activated receptor α (PPARα) agonists on leucine-induced phosphorylation of translational targets in C2C12 cells (2008)
  • Author(s): Nakai, N., F. Kawano, M. Terada, Y. Oke, T. Ohira, Y. Ohira
  • Journal Title: Biochim. Biophys. Acta 1780 Pages: 1101-1105
  • Peer Reviewed
• [Journal Article] Essential role of satellite cells in the growth of rat soleus muscle fibers (2008)
  • Author(s): Kawano, F., Y. Takeno, N. Nakai, Y. Higo, M. Terada, T. Ohira, I. Nonaka, Y. Ohira
  • Journal Title: Am.J.Physiol. Cell Physiol. 295 Pages: C458-C467
  • Peer Reviewed
• [Presentation] Effects of macrophage on unloading/reloading-related regulation of muscle fiber size in op/op mice (2009)
  • Author(s): Ohira, T., X. D. Wang, F. Kawano, M. Terada, H. Yamamoto, T. Ito, N. Nakai, K. Goto, Y. Ohira
  • Organizer: Experimental Biology
  • Place of Presentation: New Orleans, Louisiana, U.S.A.
  • Year and Date: 20090418-20090422
• [Presentation] 神経・筋の特性は筋が決める?!(特別講演) (2009)
  • Author(s): 大平充宣
  • Organizer: 日本体力医学会・第13回東海地方会
  • Place of Presentation: 名古屋大学
  • Year and Date: 2009-03-15
• [Presentation] How can we promote the regeneration of skeletal muscles? Systemic and cellular mechanisms in physiology of motor system (2009)
  • Author(s): Ohira, Y., K. Goto, T. Ohira, H. Okabe
  • Organizer: 5th Russian National School with Int'l. Participation on Muscle and Exercise Physiology, Russian Academy of Sciences
  • Place of Presentation: Moscow, Russia
  • Year and Date: 2009-02-03
• [Presentation] Mechanical stress に応じた衛星細胞の特性が関与した骨格筋の可塑性。シンポジウム "メカニカルストレスに対する筋・骨格系の応答の分子機構" (2008)
  • Author(s): 大平充宣, 後藤勝正
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会・合同大会、神戸ポートアイランド
  • Year and Date: 2008-12-12
• [Presentation] Neuromuscular adaptation to use and/or disuse : Role of satellite cells (2008)
  • Author(s): Ohira, Y.
  • Organizer: 6th International Conference of Sport Science (Special lecture, p. 67)
  • Place of Presentation: Hochiminh City, Vietnam
  • Year and Date: 2008-08-29
• [Book] Neuromuscular Regeneration, Graduate School of Medicine and Frontier Biosciences (2009)
  • Author(s): Ohira, Y., Ed.
  • Publisher: Osaka University
• [Book] Muscle Cell Physiology (2009)
  • Author(s): Ohira, Y., Ed.
  • Publisher: Osaka University Press
• [Remarks]
  • URL: http://hw001.gate01.com/kawaco/