2011 Fiscal Year Final Research Report
Cellular Systems Involved in Development and Regulation of Toxicity of Methylmercury
| Project/Area Number |
19101003
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Tohoku University |
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Principal Investigator |
NAGANUMA Akira 東北大学, 大学院・薬学研究科, 教授 (80155952)
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| Co-Investigator(Kenkyū-buntansha) |
KUGE Shusuke 東北大学, 大学院・薬学研究科, 准教授 (50186376)
HWANG Gi-wook 東北大学, 大学院・薬学研究科, 講師 (00344680)
TAKAHASHI Tsutomu 東北大学, 大学院・薬学研究科, 助教 (00400474)
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| Project Period (FY) |
2007 – 2011
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| Keywords | トキシコロジー |
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| Research Abstract |
In the present study, we successfully identified several proteins which ubiquitinized in cells and have enhancing or reducing effects against methylmercury toxicity. We also found many new facts which had not been known until now by experiments examining both mechanisms of action of these proteins and the regulation mechanisms of decomposition of these proteins by ubiquitin proteasome system. From these results, it was suggested that methylmercury toxicity is determined by the mechanism intricately related to many factors within the cells.
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[Journal Article] Characterization of antioxidant protection of cultured neural progenitor cells (NPC)against methylmercury (Mega)toxicity2009
Author(s)
Watanabe, J., Nakamachi, T., Ogawa, T., Naganuma, A., Nakamura, M., Shioda, S. and Nakajo, S.
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Journal Title
J. Toxicol. Sci.
Volume: 34
Pages: 315-325
URL
Peer Reviewed
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[Journal Article] siRNA-mediated inhibition of phosphatidylinositol glycan class B (PIGB)confers resistance to methyl mercury in HEK293 cells2007
Author(s)
Hwang, G. W., Hayashi, T., Kita, K., Takahashi, T., Kuge, S. and Naganuma, A.
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Journal Title
J. Toxicol. Sci.
Volume: 32
Pages: 581-583
URL
Peer Reviewed
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