2010 Fiscal Year Final Research Report
Advanced Control of Catalytic Activity and Stereoselectivity in Catalytic Asymmetric Reactions
| Project/Area Number |
19105002
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Synthetic chemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
HAYASHI Tamio Kyoto University, 大学院・理学研究科, 教授 (00093295)
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| Research Collaborator |
SHIRAKAWA Eiji 京都大学, 大学院・理学研究科, 准教授 (70273472)
NISHIMURA Takahiro 京都大学, 大学院・理学研究科, 講師 (50335197)
SHINTANI Ryo 京都大学, 大学院・理学研究科, 助教 (50372561)
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| Project Period (FY) |
2007 – 2010
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| Keywords | 触媒的不斉合成 / 遷移金属錯体触媒 / 不斉配位子 / キラルジエン配位子 / 触媒活性 / 不斉付加反応 / 不斉重合 |
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| Research Abstract |
One of the most important subjects in studying asymmetric catalysis is development of new chiral ligands which have both high catalytic activity and high enantioselectivity. We have successfully developed an entirely new type of chiral ligands which have olefins as coordinating functionalities to metal catalysts. Among them, chiral diene ligands showed great performance in terms of both catalytic activity and enantioselectivity in rhodium- and iridium-catalyzed asymmetric carbon-carbon bond forming reactions.
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[Journal Article] Iridium/Chiral Diene-Catalyzed Asymmetric 1, 6-Addition of Arylboroxines to α,β,γ,δ-Unsaturated Carbonyl Compounds.2010
Author(s)
Nishimura, T., Yasuhara, Y., Sawano, T., Hayashi, T.
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Journal Title
J.Am.Chem.Soc. 132
Pages: 7872-7873
Peer Reviewed
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[Journal Article] Chiral Tetrafluorobenzobarrelenes as Effective Ligands for Rhodium-Catalyzed Asymmetric 1, 4-Addition of Arylboroxines to β, β-Disubstituted α, β-Unsaturated Ketones.2010
Author(s)
Shintani, R., Takeda, M., Nishimura, T., Hayashi, T.
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Journal Title
Angew.Chem.Int.Ed. 49
Pages: 3969-3971
Peer Reviewed
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[Journal Article] Chiral Tetrafluorobenzobarrelene Ligands for the Rhodium-Catalyzed Asymmetric Cycloisomerization of Oxygen-and Nitrogen-Bridged 1, 6-Enynes.2010
Author(s)
Nishimura, T., Kawamoto, T., Nagaosa, M., Kumamoto, H., Hayashi, T.
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Journal Title
Angew.Chem.Int.Ed. 49
Pages: 1638-1641
Peer Reviewed
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[Journal Article] Rhodium-Catalyzed Asymmetric Addition of Arylboronic Acids to β-Phthaliminoacrylate Esters toward the Synthesis of β-Amino Acids.2010
Author(s)
Nishimura, T., Wang, J., Nagaosa, M., Okamoto, K., Shintani, R., Kwong, F.-Y., Yu, W.-Y., Chan, A.S.C., Hayashi, T.
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Journal Title
J.Am.Chem.Soc. 132
Pages: 464-465
Peer Reviewed
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[Journal Article] Sodium Tetraarylborates as Effective Nucleophiles in the Rhodium/Diene-Catalyzed 1, 4-Addition to β, β-Disubstituted α, β-Unsaturated Ketones : Catalytic Asymmetric Construction of Quaternary Carbon Stereocenters.2009
Author(s)
Shintani, R., Tsutsumi, Y., Nagaosa, M., Nishimura, T., Hayashi, T.
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Journal Title
J.Am.Chem.Soc. 131
Pages: 13588-13589
Peer Reviewed
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[Journal Article] Tuning the Chiral Environment of C_2-Symmetric Diene Ligands : Development of 3, 7-Disubstituted Bicyclo[3.3.1]nona-2, 6-dienes.2009
Author(s)
Shintani, R., Ichikawa, Y., Takatsu, K., Chen, F.-X., Hayashi, T.
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Journal Title
J.Org.Chem. 74
Pages: 869-873
Peer Reviewed
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[Journal Article] Organo[2-(hydroxymethyl)phenyl]dimethylsilanes as Mild and Reproducible Agents for Rhodium-Catalyzed 1, 4-Addition Reactions.2007
Author(s)
Nakao, Y., Chen, J.-S., Imanaka, H., Hiyama, T., Ichikawa, Y., Duan, W.-L., Shintani, R., Hayashi, T.
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Journal Title
J.Am.Chem.Soc. 129
Pages: 9137-9143
Peer Reviewed
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