2011 Fiscal Year Final Research Report
Osmoregulatory MAP kinase signal transduction pathway
| Project/Area Number |
19107004
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional biochemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SAITO Haruo 東京大学, 医科学研究所, 教授 (60114485)
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| Project Period (FY) |
2007 – 2011
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| Keywords | 細胞内シグナル伝達 / ストレス応答 / MAPキナーゼ / 浸透圧センサー / 酵母 |
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| Research Abstract |
When exposed to environmental hyperosmolarity, the budding yeast Saccharomyces cerevisiae activates the Hog1 MAP kinase signal pathway, which governs an array of adaptive responses. In this project, we investigated how the activity of the Hog1 MAPK pathway is regulated by the two newly discovered osmosensors Hkr1 and Msb2. We also investigated the roles of the membrane anchor protein Opy2, membrane protein Sho1, and the adaptor protein Ste50 in dynamic regulation of the Hog1 MAPK pathway.
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