2011 Fiscal Year Final Research Report
Studies on molecular mechanisms of lipid accumulation in adipocytes for anti-metabolic syndrome
| Project/Area Number |
19108002
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Food science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SATO Ryuichiro 東京大学, 大学院・農学生命科学研究科, 教授 (50187259)
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| Co-Investigator(Kenkyū-buntansha) |
INOUE Jun 東京大学, 大学院・農学生命科学研究科, 講師 (70323962)
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| Project Period (FY) |
2007 – 2011
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| Keywords | 脂肪細胞 / 脂肪滴 / トリグリセリド / メタボリックシンドローム / 抗肥満 / エネルギー |
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| Research Abstract |
Adipocytes in adipose tissues store energy as triglycerides within lipid droplets and provide energy by degrading them when required. Excess storage of triglycerides in lipid droplets leads to obesity, which causes metabolic syndrome. To explore molecular mechanism of lipid droplet formation in adipocytes, molecular cell biological studies were carried out. We succeeded to identify a couple of novel factors that are deeply involved in lipid accumulation in adipocytes. Moreover, an assay system to evaluate the activity of food factors that increase energy expenditure in adipocytes was established. Using this system, a citrus limonoid was found to be a novel anti-obesity agent.
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[Journal Article] Light-dependent and circadian clock-regulated activation of sterol regulatory element-binding protein, X-box-binding protein 1, and heat shock factor pathways2011
Author(s)
Hatori M, Hirota T, Iitsuka M, Kurabayashi N, Haraguchi S, Kokame K, Sato R, Nakai A, Miyata T, Tsutsui K, and Fukada Y
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Journal Title
Proc. Natl. Acad. Sci. U S A
Volume: 108
Pages: 4864-4869
DOI
Peer Reviewed
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