2011 Fiscal Year Final Research Report
Translational research on novel peptides in veterinary and livestock science
| Project/Area Number |
19108004
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAHARA Keiko 宮崎大学, 農学部, 准教授 (90315359)
YASUDA Masahiro 宮崎大学, 農学部, 准教授 (10336290)
NAGANOBU Kiyokazu 宮崎大学, 農学部, 教授 (40264353)
KATAYAMA Teturo 宮崎大学, フロンティア科学実験総合センター, 准教授 (30264352)
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| Project Period (FY) |
2007 – 2011
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| Keywords | トランスレーショナルリサーチ / グレリン / 遺伝性肥満 / ニューロメジンS |
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| Research Abstract |
Canine and cattle ghrelin were purified and identified. The canine ghrelin was very effective for anorexia in companion animals, and this effect was applied to international patent. We discovered that the des-acyl ghrelin resulted in decrease of body temperature and this action had therapeutic value for heatstroke during summer in cattle(international patent application). Treatment with cattle ghrelin significantly increased milk yield in daily cattle. In addition, we clarified the many novel physiological functions of neuromedin S, such as antidiuresis. We produced Daruma mice on the C57BL/6J background, and showed that Daruma mice exhibited unique characteristics and may be a good model for studying human metabolic syndrome and antidiabetic drug.
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