Visualization of oscillation for stress signal and molecular genetic study of establishment of cell community

2011 Fiscal Year Final Research Report

• Project/Area Number: 19109003
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: General medical chemistry
• Research Institution: The University of Tokyo
• Principal Investigator: MIURA Masayuki 東京大学, 大学院・薬学系研究科, 教授 (50202338)
• Project Period (FY): 2007 – 2011
• Keywords: 発生 / 細胞社会 / カスパーゼ / 分化 / ショウジョウバエ / マウス

Research Abstract

During animal development, differentiating cells face to trial and error process and acquire both intrinsic and extrinsic stress. Caspases are activated as one of stress responses. In this study, we established in vivo imaging system to monitor caspase activation. Live imaging of cell death and caspase activation allowed us to document the role of apoptosis signaling to establish the cellular communities during development.

Research Products

• [Journal Article] Live imaging of apoptosis in a novel transgenic mouse highlights its role in neural tube closure (2011)
  • Author(s): Yamaguchi, Y., Shinotsuka, N., Nonomura, K., Takemoto, K., Kuida, K., Yoshida, H., and Miura, M
  • Journal Title: J. Cell Biol Volume: 195 Pages: 1047-1060
  • DOI: DOI:10.1083/jcb.201104057
• [Journal Article] Conserved metabolic energy production pathways govern Eiger/TNF-induced non-apoptotic cell death (2011)
  • Author(s): Kanda, H., Igaki, T., Okano, H., and Miura, M.
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 108 Pages: 18977-18982
  • DOI: DOI:10.1073/pnas.1103242108
• [Journal Article] Non-autonomusapoptosis is triggered by local cell cycl eprogression during epithelial replacement in Drosophila (2011)
  • Author(s): Nakajima, Y-I, Kuranaga, E., Sugimura, K., Miyawaki, A., and Miura, M.
  • Journal Title: Mol. Cell Biol Volume: 31 Pages: 2499-2512
  • DOI: DOI:10.1128/MCB.01046-10
• [Journal Article] Apoptosis controls the speed of looping morphogenesis in Drosophila male terminalia (2011)
  • Author(s): Kuranaga, E., Matsunuma, T., Kanuka, H., Takemoto, K., Koto, A., Kimura, K and Miura, M.
  • Journal Title: Development Volume: 138 Pages: 1493-1499
  • DOI: DOI:10.1242/dev.058958
• [Journal Article] Aging causes distinct characteristics of polyglutamine amyloids in vivo (2011)
  • Author(s): Tonoki, A., E. Kuranaga, N. Ito, Y. Nekooki-Machida, Tanaka, M., and Miura, M.
  • Journal Title: Genes to Cells Volume: 16 Pages: 557-564
  • DOI: DOI:10.1111/j.1365-2443.2011.01505.x
• [Journal Article] Apoptosis ensures spacing pattern formation of Drosophila sensory organs (2011)
  • Author(s): Koto, A., Kuranaga, E., and Miura, M.
  • Journal Title: Current Biol Volume: 21 Pages: 278-287
  • DOI: DOI:10.1016/j.cub.2011.01.015
• [Journal Article] Who lives and who dies : role of apoptosis in quashing developmental errors (2011)
  • Author(s): Koto, A., and Miura, M.
  • Journal Title: Comm. Integ. Biol Volume: 4 Pages: 495-497
  • DOI: DOI:10.1016/j.cub.2011.0
• [Journal Article] Apoptotic and non-apoptotic caspase functions in neural development (2011)
  • Author(s): Miura, M.
  • Journal Title: Neurochemical Res Volume: 36 Pages: 1253-1260
  • DOI: DOI:10.1007/s11064-010-0341-x
• [Journal Article] Active participation of cell death in development and organismal homeostasis (2011)
  • Author(s): Miura, M
  • Journal Title: Dev. Growth. Diff Volume: 53 Pages: 125-136
  • DOI: DOI:10.1111/j.1440-169X.2010.01228.x
• [Journal Article] Maturation of the olfactory sensory neurons by Apaf-1/caspase-9-mediated caspase activity (2010)
  • Author(s): Ohsawa, S., Hamada, S., Kuida, K., Yoshida, H., Igaki, T., and Miura, M.
  • Journal Title: Proc. Natl. Acad. Sci. Volume: 107 Pages: 13366-13371
  • DOI: DOI:10.1073/pnas.0910488107
• [Journal Article] Simultaneous expression of different transgenes in neurons and glia by combining in utero electroporation with the Tol2 transposon mediated gene transfer system (2010)
  • Author(s): Yoshida, A., Yamaguchi, Y., Nonomura, K., Kawakami, K., Takahashi, Y., and Miura, M
  • Journal Title: Genes to Cells Volume: 15 Pages: 501-512
  • DOI: DOI:10.1111/j.1365-2443.2010.01397.x
• [Journal Article] Temporal regulation of Drosophila IAP determines the dual functions of caspases in sensory organ development (2009)
  • Author(s): Koto, A., Kuranaga, E., and Miura, M
  • Journal Title: J. Cell Biol Volume: 187 Pages: 219-321
  • DOI: DOI:10.1083/jcb.200905110
• [Journal Article] Caspase-9 activation revealed by Semaphorin 7A cleavage is independent of apoptosis in the aged olfactory bulb (2009)
  • Author(s): Ohsawa, S., Hamada, S., Asou, H., Kuida, K., Uchiyama, Y., Yoshida, H., and Miura, M
  • Journal Title: J. Neurosci Volume: 29 Pages: 11385-11392
  • DOI: DOI:10.1523/JNEUROSCI.4780-08.2009
• [Journal Article] Caspase-mediated changes in Histone H1 in early apoptosis : prolonged caspase activation in developing olfactory sensory neurons (2008)
  • Author(s): Ohsawa, S., Hamada, S., Yoshida, H., and Miura, M
  • Journal Title: Cell Death Diff Volume: 15 Pages: 1429-1439
  • DOI: DOI:10.1038/cdd.2008.71
• [Journal Article] Local initiation of caspase activation in Drosophila salivary gland programmed cell death in vivo (2007)
  • Author(s): Takemoto, K., Kuranaga, E., Tonoki, A., Nagai, T., Miyawaki, A., and Miura, M
  • Journal Title: Proc. Natl. Acad. Sci. Volume: 104 Pages: 13367-13372
  • DOI: DOI:10.1073_pnas.0702733104
• [Presentation] Physiological function of caspases in organogenesis and tissue remodeling (2011)
  • Author(s): Miura, M
  • Organizer: 25^<th> Annual French Drosophila Conference
  • Place of Presentation: Lyon, France
  • Year and Date: 20111017-20
• [Presentation] The replacement boundary coordinates epidermal remodeling in Drosophila (2011)
  • Author(s): Miura, M
  • Organizer: 第63回日本細胞生物学会シンポジウム
  • Place of Presentation: 札幌、日本
  • Year and Date: 20110627-29
• [Presentation] Caspase regulates axon pathfinding and maturation of mouse olfactory neurons (2010)
  • Author(s): Miura, M.
  • Organizer: International Symposium on Morphological Sciences
  • Place of Presentation: Taormina, Italy
  • Year and Date: 20100918-22
• [Presentation] Roles of programmed cell death signaling in Drosophila sensory organ development (2010)
  • Author(s): Miura, M.
  • Organizer: International Symposium on "Cell Cycle and Development"
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 20100315-17
• [Presentation] TNF signaling and its physiological roles in Drosophila (2009)
  • Author(s): Miura, M
  • Organizer: 12^<th> International TNF conference
  • Place of Presentation: Madrid, Spain
  • Year and Date: 20090426-29
• [Presentation] In vivo dynamics of cell death signaling in the Drosophila sensory organ development (2008)
  • Author(s): Miura, M.
  • Organizer: International Cell Death Society Symposium
  • Place of Presentation: Shanghai, China
  • Year and Date: 20080606-09
• [Presentation] Non-apoptotic function of caspase signaling in Drosophila (2007)
  • Author(s): Miura, M
  • Organizer: Keystone Symposium on Apoptotic and Non-apoptotic Cell Death Pathways
  • Place of Presentation: Monterey, California, USA
  • Year and Date: 20070415-20
• [Remarks]
  • URL: http://www.f.u-tokyo.ac.jp/~genetics/index.html