The integrated study for molecular backgrounds and therapeutic targets of osteoarthritis : The ROAD project

2009 Fiscal Year Self-evaluation Report

• Project/Area Number: 19109007
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Orthopaedic surgery
• Research Institution: 国立障害者リハビリテーションセンター(研究所) (2011); The University of Tokyo (2007-2010)
• Principal Investigator: NAKAMURA Kozo The University of Tokyo, 医学部附属病院, 教授 (60126133)
• Project Period (FY): 2007 – 2011
• Keywords: 変形性関節症 / 遺伝子 / ゲノム

Research Abstract

変形性関節症(OA)の予防・治療法の確立に対する社会的ニーズの高まりは疑いの余地がない。我々は最近、OAの分子メカニズム解明から画期的な予防・治療法の開発を目指した戦略的OA統合研究計画として、ROADプロジェクトを樹立した。本研究課題では、1)軟骨変性制御分子のクローニングと分子ネットワークの解明、2)重症度評価システムの開発、3)遺伝・環境因子の網羅的・系統的探索、の3テーマについての研究を行う。

Research Products

• [Journal Article] Akt1 in murine chondrocytes controls cartilage calcification during endochondral ossification under physiologic and pathologic conditions (2010)
  • Author(s): Fukai A, Kawamura N, Saito T, Oshima Y, Ikeda T, Kugimiya F, Higashikawa H, Yano F, Ogata N, Nakamura K, Chung UI, Kawaguchi H
  • Journal Title: Arthritis Rheum 62 Pages: 826-836
• [Journal Article] Mechanisms underlying catabolic and anabolic functions of parathyroid hormone on bone by combination of culture systems of mouse cells (2010)
  • Author(s): Shinoda Y, Kawaguchi H, Higashikawa A, Hirata M, Miura T, Saito T, Nakamura K, Chung UI, Ogata N
  • Journal Title: J Cell Biochem 109 Pages: 755-763
• [Journal Article] Locomotive syndrome : disability-free life expectancy and locomotive organ health in a "super-aged" society (2009)
  • Author(s): Nakamura K
  • Journal Title: J Orthop Sci 14 Pages: 1-2
• [Journal Article] Regulation of osteoarthritis development by Wnt-β-catenin signaling through the endochondral ossification process (2009)
  • Author(s): Kawaguchi H
  • Journal Title: J Bone Miner Res 24 Pages: 8-11
• [Journal Article] Identification of the core element responsive to runt-related transcription factor 2 in the promoter of human type x collagen gene (2009)
  • Author(s): Higashikawa A, Saito T, Ikeda T, Kamekura S, Kawamura N, Kan A, Oshima Y, Ohba S, Ogata N, Takeshita K, Nakamura K, Chung UI, Kawaguchi H
  • Journal Title: Arthritis Rheum 60 Pages: 166-178
• [Journal Article] C/EBPβ promotes transition from proliferation to hypertrophic differentiation of chondrocytes through transactivation of p57^<Kip2> (2009)
  • Author(s): Hirata M, Kugimiya F, Fukai A, Ohba S, Kawamura N, Ogasawara T, Kawasaki Y, Saito T, Yano F, Ikeda T, Nakamura K, Chung UI, Kawaguchi H
  • Journal Title: PLoS ONE 4 Pages: e4543
• [Journal Article] Association of occupational activity with radiographic knee osteoarthritis and lumbar spondylosis in elderly patients of population-based cohorts : A large-scale population-based study (2009)
  • Author(s): Muraki S, Akune T, Oka H, Mabuchi A, En-yo Y, Yoshida M, Saika A, Nakamura K, Kawaguchi H, Yoshimura N
  • Journal Title: Arthritis Rheum 61 Pages: 779-786
• [Journal Article] Epidemiology of lumbar osteoporosis and osteoarthritis and their causal relationship-Is osteoarthritis a predictor for osteoporosis or vice versa?: The Miyama study (2009)
  • Author(s): Yoshimura N, Muraki S, Oka H, Kinoshita H, Yoshida M, Mabuchi A, Kawaguchi H, Nakamura K, Akune T
  • Journal Title: Osteoporosis Int 20 Pages: 999-1008
• [Journal Article] Transcriptional induction of SOX9 by NF-κB family member RelA in chondrogenic cells (2009)
  • Author(s): Ushita M, Saito T, Ikeda T, Yano F, Higashikawa A, Ogata N, Chung UI, Nakamura K, Kawaguchi H
  • Journal Title: Osteoarthritis Cartilage 17 Pages: 1065-1075
• [Journal Article] Prevalence of radiographic lumbar spondylosis and its association with low back pain in the elderly of population-based cohorts : the ROAD study (2009)
  • Author(s): Muraki S, Oka H, Mabuchi A, Akune T, En-yo Y, Yoshida M, Saika A, Suzuki T, Yoshida H, Ishibashi H, Yamamoto S, Nakamura K, Kawaguchi H, Yoshimura N
  • Journal Title: Ann Rheum Dis 68 Pages: 1401-1406
• [Journal Article] Prevalence of knee osteoarthritis, lumbar spondylosis, and osteoporosis in Japanese men and women : the research on osteoarthritis/osteoporosis against disability study (2009)
  • Author(s): Yoshimura N, Muraki S, Oka H, Mabuchi A, En-Yo Y, Yoshida M, Saika A, Yoshida H, Suzuki T, Yamamoto S, Ishibashi H, Kawaguchi H, Nakamura K, Akune T
  • Journal Title: J Bone Miner Metab 27 Pages: 620-628
• [Journal Article] Prevalence of radiographic knee osteoarthritis and its association with knee pain in the elderly of Japanese population-based cohorts : The ROAD study (2009)
  • Author(s): Muraki S, Oka H, Akune T, Mabuchi A, En-yo Y, Yoshida M, Saika A, Suzuki T, Yoshida H, Ishibashi H, Yamamoto S, Nakamura K, Kawaguchi H, Yoshimura N
  • Journal Title: Osteoarthritis Cartilage 17 Pages: 1137-1143
• [Journal Article] Screening of chondrogenic factors by a real-time fluorescence monitoring cell line ATDC5-C2ER : Identification of sorting nexin 19 as a novel factor (2009)
  • Author(s): Kan A, Ikeda T, Saito T, Yano F, Fukai A, Ogata N, Nakamura K, Chung UI, Kawaguchi H
  • Journal Title: Arthritis Rheum 60 Pages: 3314-3323
• [Journal Article] Low dietary vitamin K intake is associated with radiographic knee osteoarthritis in the Japanese elderly : Dietary survey in a population-based cohort of the ROAD study (2009)
  • Author(s): Oka H, Akune T, Muraki S, Mabuchi A, En-yo Y, Yoshida M, Saika A, Sasaki S, Nakamura K, Kawaguchi H, Yoshimura N
  • Journal Title: J Orthop Sci 14 Pages: 687-692
• [Journal Article] Selection of highly osteogenic and chondrogenic cells from bone marrow stromal cells in biocompatible polymer-coated plates (2009)
  • Author(s): Liu G, Iwata K, Ogasawara T, Watanabe J, Fukazawa K, Ishihara K, Asawa Y, Fujihara Y, Chung UI, Moro T, Takatori Y, Takato T, Nakamura K, Kawaguchi H, Hoshi K
  • Journal Title: J Biomed Mater Res A 92 Pages: 1273-1282
• [Journal Article] Assessment of vertebral fracture risk and therapeutic effects of alendronate in postmenopausal women using a quantitative computed tomography-based nonlinear finite element method (2009)
  • Author(s): Imai K, Ohnishi I, Matsumoto T, Yamamoto S, Nakamura K
  • Journal Title: Osteoporos Int 20 Pages: 801-810
• [Journal Article] Prediction of vertebral strength under loading conditions occurring in activities of daily living using a computed tomography-based nonlinear finite element method (2009)
  • Author(s): Matsumoto T, Ohnishi I, Bessho M, Imai K, Ohashi S, Nakamura K
  • Journal Title: Spine 34 Pages: 1464-1469
• [Journal Article] Prediction of proximal femur strength using a CT-based nonlinear finite element method : differences in predicted fracture load and site with changing load and boundary conditions (2009)
  • Author(s): Bessho M, Ohnishi I, Matsumoto T, Ohashi S, Matsuyama J, Tobita K, Kaneko M, Nakamura K
  • Journal Title: Bone 45 Pages: 226-231
• [Journal Article] The efficacy of prostaglandin E1 derivative in patients with lumbar spinal stenosis (2009)
  • Author(s): Matsudaira K, Seichi A, Kunogi J, Yamazaki T, Kobayashi A, Anamizu Y, Kishimoto J, Hoshi K, Takeshita K, Nakamura K
  • Journal Title: Spine 34 Pages: 115-120
• [Journal Article] Modified fenestration with restorative spinoplasty for lumbar spinal stenosis (2009)
  • Author(s): Matsudaira K, Yamazaki T, Seichi A, Hoshi K, Hara N, Ogiwara S, Terayama S, Chikuda H, Takeshita K, Nakamura K
  • Journal Title: J Neurosurg Spine 10 Pages: 587-594
• [Journal Article] A "super-aged" society and the "locomotive syndrome" (2008)
  • Author(s): Nakamura K
  • Journal Title: J Orthop Sci 13 Pages: 1-2
• [Journal Article] Endochondral ossification signals in cartilage degradation during osteoarthritis progression in experimental mouse models (2008)
  • Author(s): Kawaguchi H
  • Journal Title: Mol Cells 25 Pages: 1-6
• [Journal Article] Analysis of the Runx2 promoter in osseous and non-osseous cells and identification of HIF2A as a potent transcriptional activator (2008)
  • Author(s): Tamiya H, Ikeda T, Jung JH, Saito T, Jung YK, Kawaguchi H, Ohba S, Chung UI, Choi JY
  • Journal Title: Gene 416 Pages: 53-60
• [Journal Article] Association of microsomal prostaglandin E synthase 1 deficiency with impaired fracture healing, but not with bone loss or osteoarthritis, in mouse models of skeletal disorders (2008)
  • Author(s): Yamakawa K, Kamekura S, Kawamura N, Saegusa M, Kamei D, Murakami M, Kudo I, Uematsu S, Akira S, Chung UI, Nakamura K, Kawaguchi H
  • Journal Title: Arthritis Rheum 58 Pages: 172-183
• [Journal Article] Patched1 haploinsufficiency increases adult bone mass and modulates Gli3 repressor activity (2008)
  • Author(s): Ohba S, Kawaguchi H, Kugimiya F, Ogasawara T, Kawamura N, Saito T, Ikeda T, Fujii K, Miyajima T, Kuramochi A, Miyashita T, Oda H, Nakamura K, Takato T, Chung UI
  • Journal Title: Dev Cell 14 Pages: 689-699
• [Journal Article] Phosphorylation of GSK-3β by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes (2008)
  • Author(s): Kawasaki Y, Kugimiya F, Chikuda H, Kamekura S, Ikeda T, Kawamura N, Saito T, Shinoda Y, Higashikawa A, Yano F, Ogasawara T, Ogata N, Hoshi K, Hofmann F, Woodgett JR, Nakamura K, Chung UI, Kawaguchi H
  • Journal Title: J Clin Invest 118 Pages: 2506-2515
• [Journal Article] The Distinct role of the Runx proteins in chondrocyte differentiation and intervertebral disc degeneration : Findings in murine models and in human disease (2008)
  • Author(s): Sato S, Kimura A, Ozdemir J, Asou Y, Miyazaki M, Jinno T, Ae K, Liu X, Osaki M, Takeuchi Y, Fukumoto S, Kawaguchi H, Haro H, Shinomiya K, Karsenty G, Takeda S
  • Journal Title: Arthritis Rheum 58 Pages: 2764-2775
• [Journal Article] Kruppel-like factor 5 causes cartilage degradation through transactivation of matrix metalloproteinase 9 (2008)
  • Author(s): Shinoda Y, Ogata N, Higashikawa A, Manabe I, Shindo T, Yamada T, Kugimiya F, Ikeda T, Kawamura N, Kawasaki Y, Tsushima K, Takeda N, Nagai R, Hoshi K, Nakamura K, Chung UI, Kawaguchi H
  • Journal Title: J Biol Chem 283 Pages: 24682-24689
• [Journal Article] Pivotal role of Bcl-2 family proteins in the regulation of chondrocyte apoptosis (2008)
  • Author(s): Oshima Y, Akiyama T, Hikita A, Iwasawa M, Nagase Y, Nakamura M, Wakeyama H, Kawamura N, Ikeda T, Chung UI, Hennighausen L, Kawaguchi H, Nakamura K, Tanaka S
  • Journal Title: J Biol Chem 283 Pages: 26499-26508
• [Journal Article] Fully automatic quantification of knee osteoarthritis severity on plain radiographs (2008)
  • Author(s): Oka H, Muraki S, Akune T, Mabuchi A, Suzuki T, Yoshida H, Yamamoto S, Nakamura K, Yoshimura N, Kawaguchi H
  • Journal Title: Osteoarthritis Cartilage 16 Pages: 1300-1306
• [Journal Article] In vivo assessment of lumbar vertebral strength in elderly women using computed tomography-based nonlinear finite element model (2008)
  • Author(s): Imai K, Ohnishi I, Yamamoto S, Nakamura K
  • Journal Title: Spine 33 Pages: 27-32
• [Journal Article] A new method for evaluation of fracture healing by echo tracking (2008)
  • Author(s): Matsuyama J, Ohnishi I, Sakai R, Bessho M, Matsumoto T, Miyasaka K, Harada A, Ohashi S, Nakamura K
  • Journal Title: Ultrasound Med Biol 34 Pages: 775-783
• [Journal Article] Control of fracture reduction robot using force/torque measurement (2008)
  • Author(s): Douke T, Nakajima Y, Mori Y, Onogi S, Sugita N, Mitsuishi M, Bessho M, Ohhashi S, Tobita K, Ohnishi I, Sakuma I, Dohi T, Maeda Y, Koyama T, Sugano N, Yonenobu K, Matsumoto Y, Nakamura K
  • Journal Title: Conf Proc IEEE Eng Med Biol Soc 2008 Pages: 3265-3268
• [Journal Article] Early functional improvement after a modified ligament reconstruction tendon interposition arthroplasty for thumb basal joint arthritis (2008)
  • Author(s): Miura T, Osuka K, Itoh S, Nakagawa T, Kawano H, Nakamura K
  • Journal Title: Hand Surg 13 Pages: 153-158
• [Journal Article] Tumor necrosis factor-alpha inhibits chondrogenic differentiation of synovial fibroblasts through p38 mitogen activating protein kinase pathways (2008)
  • Author(s): Okuma-Yoshioka C, Seto H, Kadono Y, Hikita A, Oshima Y, Kurosawa H, Nakamura K, Tanaka S
  • Journal Title: Mod Rheumatol 18 Pages: 366-378
• [Journal Article] S100A1 and B, transcriptional targets of SOX trio, inhibit terminal differentiation of chondrocytes (2007)
  • Author(s): Saito T, Ikeda T, Nakamura K, Chung UI, Kawaguchi H
  • Journal Title: EMBO Rep 8 Pages: 504-509
• [Journal Article] Identification of a potent combination of osteogenic genes for bone regeneration using embryonic stem (ES) cell-based sensor (2007)
  • Author(s): Ohba S, Ikeda T, Kugimiya F, Yano F, Lichtler AC, Nakamura K, Takato T, Kawaguchi H, Chung UI
  • Journal Title: FASEB J 21 Pages: 1777-1787
• [Journal Article] A novel osteogenic helioxanthin-derivative acts in a BMP-dependent manner (2007)
  • Author(s): Ohba S, Nakajima K, Komiyama Y, Kugimiya F, Igawa K, Itaka K, Moro T, Nakamura K, Kawaguchi H, Takato T, Chung UI
  • Journal Title: Biochem Biophys Res Commun 357 Pages: 854-860
• [Journal Article] Identification and characterization of the human SOX6 promoter (2007)
  • Author(s): Ikeda T, Saito T, Ushita M, Yano F, Kan A, Itaka K, Moro T, Nakamura K, Kawaguchi H, Chung UI
  • Journal Title: Biochem Biophys Res Commun 357 Pages: 383-390
• [Journal Article] Optimal combination of soluble factors for tissue engineering of permanent cartilage from cultured human chondrocytes (2007)
  • Author(s): Liu G, Kawaguchi H, Ogasawara T, Asawa Y, Kishimoto JI, Takahashi T, Chung UI, Yamaoka H, Asato H, Nakamura K, Takato T, Hoshi K
  • Journal Title: J Biol Chem 282 Pages: 20407-20415
• [Journal Article] Diet and lifestyle associated with increased bone mineral density : cross-sectional study of Japanese elderly women at an osteoporosis outpatient clinic (2007)
  • Author(s): Muraki S, Yamamoto S, Ishibashi H, Oka H, Yoshimura N, Kawaguchi H, Nakamura K
  • Journal Title: J Orthop Sci 12 Pages: 317-320
• [Journal Article] GSK-3β controls osteogenesis through regulating Runx2 activity (2007)
  • Author(s): Kugimiya F, Kawaguchi H, Ohba S, Kawamura N, Hirata M, Chikuda H, Azuma Y, Woodgett JR, Nakamura K, Chung UI
  • Journal Title: PLoS ONE 2 Pages: e837
• [Journal Article] Prevention of cartilage destruction with intraarticular osteoclastogenesis inhibitory factor/osteoprotegerin in a murine model of osteoarthritis (2007)
  • Author(s): Shimizu S, Asou Y, Itoh S, Cung UI, Kawaguchi H, Shinomiya K, Muneta T
  • Journal Title: Arthritis Rheum 56 Pages: 3358-3365
• [Journal Article] Continuous activation of Gαq in osteoblasts results in osteopenia through impaired osteoblast differentiation (2007)
  • Author(s): Ogata N, Kawaguchi H, Chung UI, Roth SI, Segre GV
  • Journal Title: J Biol Chem 282 Pages: 35757-64
• [Journal Article] Prediction of strength and strain of the proximal femur by a CT-based finite element method (2007)
  • Author(s): Bessho M, Ohnishi I, Matsuyama J, Matsumoto T, Imai K, Nakamura K
  • Journal Title: J Biomech 40 Pages: 1745-1753
• [Journal Article] Redifferentiation of dedifferentiated bovine articular chondrocytes enhanced by cyclic hydrostatic pressure under a gas-controlled system (2007)
  • Author(s): Kawanishi M, Oura A, Furukawa K, Fukubayashi T, Nakamura K, Tateishi T, Ushida T
  • Journal Title: Tissue Eng 13 Pages: 957-964
• [Journal Article] Transcriptional regulation of endochondral ossification by HIF2A during skeletal growth and osteoarthritis development
  • Author(s): Saito T, Fukai A, Mabuchi A, Ikeda T, Yano F, Ohba S, Nishida N, Akune T, Yoshimura N, Nakagawa T, Nakamura K, Tokunaga K, Chung UI, Kawaguchi H
  • Journal Title: Nature Med (in press)
• [Journal Article] Health-related quality of life with vertebral fracture, lumbar spondylosis and knee osteoarthritis in Japanese men : the ROAD study
  • Author(s): Muraki S, Akune T, Oka H, En-yo Y, Saika A, Suzuki T, Yoshida H, Ishibashi H, Tokimura F, Yamamoto S, Nakamura K, Kawaguchi H, Yoshimura N
  • Journal Title: Arch Osteoporos (in press)
• [Journal Article] Cohort profile : Research on Osteoarthritis/Osteoporosis Against Disability study
  • Author(s): Yoshimura N, Muraki S, Oka H, Kawaguchi H, Nakamura K, Akune T
  • Journal Title: Int J Epidemiol (in press)
• [Journal Article] Title : Identification of oxytetracycline as a chondrogenic compound using a cell-based screening system
  • Author(s): Hojo H, Yano F, Ohba S, Igawa K, Nakajima K, Komiyama Y, Kan A, Ikeda T, Yonezawa T, Woo JT, Takato T, Nakamura K, Kawaguchi H, Chung UI
  • Journal Title: J Bone Miner Metab (in press)
• [Presentation] Molecular backgrounds of cartilage degradation during osteoarthritis progression (Invited Lecture) (2010)
  • Author(s): Kawaguchi H
  • Organizer: 2010 Anti-aging and Well-being International Symposium
  • Place of Presentation: Daegu, Korea
  • Year and Date: 2010-02-19
• [Presentation] Therapeutic target molecules for cartilage degradation in osteoarthritis progression (Invited Lecture) (2010)
  • Author(s): Kawaguchi H
  • Organizer: System Biology and Drug Discovery
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2010-02-09
• [Presentation] A novel thienoindazole-derivative small compound induces chondrogenic differentiation without promoting hypertrophy through Runx1 (Young Investigator Award) (2009)
  • Author(s): Yano F, Ikeda T, Saito T, Ogata N, Hojo H, Kimura A, Takeda S, Takato T, Nakamura K, Kawaguchi H, Chung UI
  • Organizer: 31th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
  • Place of Presentation: Denver, Colorado, USA
  • Year and Date: 20090911-20090915
• [Presentation] Comprehensive control of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis progression (2009)
  • Author(s): Saito T, Fukai A, Ikeda T, Yano F, Hirata M, Kan A, Nakamura K, Chung UI, Kawaguchi H
  • Organizer: 31th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
  • Place of Presentation: Denver, Colorado, USA
  • Year and Date: 20090911-20090915
• [Presentation] Notch/RBPJk/Hes1 signaling controls terminal differentiation of chondrocytes during endochondral ossification (2009)
  • Author(s): Hikata T, Saito T, Takaishi H, Akiyama H, Nakamura T, Yamaguchi A, Matsumoto M, Chiba K, Toyama Y, Kawaguchi H
  • Organizer: 31th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
  • Place of Presentation: Denver, Colorado, USA
  • Year and Date: 20090911-20090915
• [Presentation] Regulator of G protein signaling (RGS)-2 enhances bone anabolic action of PTH through inhibition of Gαq/PKC pathway in osteoblasts (2009)
  • Author(s): Ogata N, Yano F, Chikazu D, Chung UI, Nakamura K, Kawaguchi H
  • Organizer: 31th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
  • Place of Presentation: Denver, Colorado, USA
  • Year and Date: 20090911-20090915
• [Presentation] Association of knee osteoarthritis, lumbar spondylosis and osteoporosis with mild cognitive impairment : The ROAD (Research on Osteoarthritis/osteoporosis Against Disability) study (2009)
  • Author(s): Yoshimura N, Muraki S, Oka H, Kawaguchi H, Nakamura K, Akune T
  • Organizer: 31th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
  • Place of Presentation: Denver, Colorado, USA
  • Year and Date: 20090911-20090915
• [Presentation] Health-related quality of life in subjects with vertebral fracture, knee osteoarthritis, lumbar spondylosis and other chronic diseases as well as low back pain and knee pain in a population-based cohort study in Japan : The ROAD study (2009)
  • Author(s): Muraki S, Akune T, Oka H, Nakamura K, Kawaguchi H, Yoshimura N
  • Organizer: 31th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
  • Place of Presentation: Denver, Colorado, USA
  • Year and Date: 20090911-20090915
• [Presentation] Identification of receptor tyrosine kinase-like orphan receptor 2 (ROR2)/WNT5B signaling as a therapeutic target against osteosarcoma (2009)
  • Author(s): Morioka K, Matsuda K, Kawano H, Nakamura K, Kawaguchi H, Nakamura Y
  • Organizer: 31th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
  • Place of Presentation: Denver, Colorado, USA
  • Year and Date: 20090911-20090915
• [Presentation] Requirement of Runx1 for chondrocyte lineage commitment (2009)
  • Author(s): Kimura A, Inose H, Fujita K, Yano F, Kawaguchi H, Chung UI, Shinomiya K, Takeda S
  • Organizer: 31th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
  • Place of Presentation: Denver, Colorado, USA
  • Year and Date: 20090911-20090915
• [Presentation] NF-kappa B family member RelA/p65, a transcription factor of Sox9, is essential for chondrogenic differentiation and skeletal growth (Young Investigator Award) (2009)
  • Author(s): Itoh S, Saito T, Ushita M, Ikeda T, Yano F, Ogata N, Chung UI, Nakamura K, Kawaguchi H
  • Organizer: 2009 World Congress on Osteoarthritis (OARSI)
  • Place of Presentation: Monteral, Quebec, Canada
  • Year and Date: 20090910-20090913
• [Presentation] Distinct transcriptional control of chondrocyte hypertrophy and cartilage degeneration by C/EBP-beta and Runx2 during endochondral ossification (2009)
  • Author(s): Hirata M, Kugimiya F, Fukai A, Saito T, Kan A, Higashikawa A, Yano F, Ikeda T, Nakamura K, Chung UI, Kawaguchi H
  • Organizer: 2009 World Congress on Osteoarthritis (OARSI)
  • Place of Presentation: Monteral, Quebec, Canada
  • Year and Date: 20090910-20090913
• [Presentation] Akt1 in chondrocytes controls cartilage calcification during osteophyte foration in osteoarthritis (2009)
  • Author(s): Fukai A, Kawamura N, Saito T, Ikeda T, Ogata N, Nakamura K, Chung UI, Kawaguchi H
  • Organizer: 2009 World Congress on Osteoarthritis (OARSI)
  • Place of Presentation: Monteral, Quebec, Canada
  • Year and Date: 20090910-20090913
• [Presentation] Association of radiographic severity of lumbar spondylosis with low back pain and related disabilities : The ROAD study (2009)
  • Author(s): Akune T, Muraki S, Oka H, Nakamura K, Kawaguchi H, Yoshimura N
  • Organizer: 2009 World Congress on Osteoarthritis (OARSI)
  • Place of Presentation: Monteral, Quebec, Canada
  • Year and Date: 20090910-20090913
• [Presentation] Automated quantification and diagnosis of the knee on plain radiographs : The ROAD study (2009)
  • Author(s): Oka H, Akune T, Muraki S, Nakamura K, Kawaguchi H, Yoshimura N
  • Organizer: 2009 World Congress on Osteoarthritis (OARSI)
  • Place of Presentation: Monteral, Quebec, Canada
  • Year and Date: 20090910-20090913
• [Presentation] Cross-linked brush-like structure of surface-modified layers gives high durability to joint replacement (2009)
  • Author(s): Kyomoto M, Moro T, Miyaji F, Yamawaki N, Kawaguchi H, Takatori Y, Nakamura K, Ishihara K
  • Organizer: 22nd annual conference of the European Society for Biomaterials (ESB)
  • Place of Presentation: Lausanne, Swiss
  • Year and Date: 20090907-20090911
• [Presentation] Cyclic GMP-dependent protein kinase II promotes chondrocyte hypertrophy and skeletal growth (2009)
  • Author(s): Kawaguchi H, Chikuda H, Kawasaki Y, Hofmann F
  • Organizer: 4th International Conference on cGMP
  • Place of Presentation: Rosensburg, Germany
  • Year and Date: 20090619-20090621
• [Presentation] Osteoarthritis, osteoporosis and cognitive impairment : the research on osteoarthritis/osteoporosis against disability study (2009)
  • Author(s): Yoshimura N. Muraki S, Oka H, Kawaguchi H, Nakamura K, Akune T
  • Organizer: 36th European Symposium on Calcified Tissues (ECTS)
  • Place of Presentation: Vienna, Austria
  • Year and Date: 20090523-20090527
• [Presentation] Full-automatic quantification of hip geometry on plain radiographs by a novel computer-assisted system (2009)
  • Author(s): Oka H, Akune T, Muraki S, Nakamura K, Kawaguchi H, Yoshimura N
  • Organizer: 36th European Symposium on Calcified Tissues (ECTS)
  • Place of Presentation: Vienna, Austria
  • Year and Date: 20090523-20090527
• [Presentation] Mouse genetics studies on molecular mechanisms underlying bone and cartilage disorders (Kappa Delta Award Paper Presentation) (2009)
  • Author(s): Kawaguchi H, Akune T, Yamada T, Ogata N
  • Organizer: 55th Annual Meeting of the Orthopaedic Research Society (ORS)
  • Place of Presentation: Las Vegas, Nevada, USA
  • Year and Date: 20090222-20090225
• [Presentation] Molecular backgrounds of cartilage degeneration during osteoarthritis progression (Special Lecture : OARSI-KORS Co-sponsored Symposium) (2009)
  • Author(s): Kawaguchi H
  • Organizer: The 35th Annual Meeting of the Korean Orthopaedic Research Society
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2009-10-14
• [Presentation] Transcriptional regulation of cartilage degeneration during osteoarthritis progression (2009)
  • Author(s): Kawaguchi H
  • Organizer: The 2nd International Cartilage and Osteoarthritis Symposium (Plenary Lecture)
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2009-10-10
• [Presentation] C/EBP-beta promotes hypertrophic differentiation of chondrocytes through transactivation of p57^<Kip2> during endochonderal ossification (Young Investigator Award) (2008)
  • Author(s): Kugimiya F, Hirata M, Ohba S, Kawamura K, Ogasawara T, Kawasaki Y, Ikeda T, Nakamura K, Chung UI, Kawaguchi H
  • Organizer: 2008 World Congress on Osteoarthritis (OARSI)
  • Place of Presentation: Rome, Italy
  • Year and Date: 20080918-20080921
• [Presentation] A Novel small thienoindazole-derivative compound promotes chondrogenic differentiation without inducing hypertrophy through production of Runx1 (Young Investigator Award) (2008)
  • Author(s): Yano F, Ikeda T, Saito T, Ogata N, Nakamura K, Takato T, Kawaguchi H, Chung UI
  • Organizer: 2008 World Congress on Osteoarthritis (OARSI)
  • Place of Presentation: Rome, Italy
  • Year and Date: 20080918-20080921
• [Presentation] Akt1 contributes to chondrocyte calcification during endochondral ossification (2008)
  • Author(s): Fukai A, Kawamura N, Nakamura K, Chung UI, Kawaguchi H
  • Organizer: 2008 World Congress on Osteoarthritis (OARSI)
  • Place of Presentation: Rome, Italy
  • Year and Date: 20080918-20080921
• [Presentation] Association of radiographic severity of knee osteoarthritis with symptomatic parameters : The ROAD study (2008)
  • Author(s): Akune T, Muraki S, Oka H, Nakamura K, Kawaguchi H, Yoshimura N
  • Organizer: 2008 World Congress on Osteoarthritis (OARSI)
  • Place of Presentation: Rome, Italy
  • Year and Date: 20080918-20080921
• [Presentation] Lateral joint space narrowing on radiographs predicts pain progression in knee osteoarthritis patients : Application of fully automatic KOACAD system to OAI public data (2008)
  • Author(s): Oka H, Akune T, Muraki S, Nakamura K, Yoshimura N, Kawaguchi H
  • Organizer: 2008 World Congress on Osteoarthritis (OARSI)
  • Place of Presentation: Rome, Italy
  • Year and Date: 20080918-20080921
• [Presentation] Biocompatible phospholipid polymer grafting on liner surface of artificial hip joints enhances the wear resistance independently of liner cross-link or femoral head material (2008)
  • Author(s): Moro T, Takatori Y, Kyomoto M, Ishihara K, Nakamura K, Kawaguchi H
  • Organizer: 2008 World Congress on Osteoarthritis (OARSI)
  • Place of Presentation: Rome, Italy
  • Year and Date: 20080918-20080921
• [Presentation] Evaluation of the usefulness of biomarkers in knee osteoarthritis or lumbar spondylosis in mass cohort study of Japan (2008)
  • Author(s): Morita M, Yamada H, Yoshimura N, Date H, Oka H, Muraki S, Akune T, Ichinose H, Kawaguchi H, Nakamura K
  • Organizer: 2008 World Congress on Osteoarthritis (OARSI)
  • Place of Presentation: Rome, Italy
  • Year and Date: 20080918-20080921
• [Presentation] Hypoxia-inducible factor 2A (HIF2A) controls sequential steps in the late stage of endochondral ossification (Young Investigator Award) (2008)
  • Author(s): Saito T, Ikeda T, Kan A, Hirata M, Fukai A, Yano F, Nakamura K, Chung UI, Kawaguchi H
  • Organizer: 2008 World Congress on Osteoarthritis (OARSI)
  • Place of Presentation: Rome, Italy
  • Year and Date: 20080918-20080921
• [Presentation] β-catenin directly binds to a specifc intracellular domain of PTH/PTHrP receptor and regulates the signaling in chondrocytes during endochondral ossification. (President's Award) (2008)
  • Author(s): Yano F, Chung UI, Ikeda T, Kawasaki Y, Kawaguchi H, Tawfeek HAW, Mahon MJ, Segre GV, Ogata N
  • Organizer: 30th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
  • Place of Presentation: Montreal, Quebec, Canada
  • Year and Date: 20080912-20080916
• [Presentation] C/EBPβ/p57^<Kip2> signaling maintains transition from proliferation to hypertrophic differentiation of chondrocytes during skeletal growth (2008)
  • Author(s): Hirata M, Kugimiya F, Ohba S, Kawamura N, Ogasawara T, Kawasaki Y, Ikeda T, Nakamura K, Chung UI, Kawaguchi H
  • Organizer: 30th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
  • Place of Presentation: Montreal, Quebec, Canada
  • Year and Date: 20080912-20080916
• [Presentation] Identification of a transcription factor p63 for transactivation of Wnt9a and Gdf5 causing joint cartilage formation (2008)
  • Author(s): Kan A, Ikeda T, Saito T, Nakamura K, Chung UI, Kawaguchi H
  • Organizer: 30th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
  • Place of Presentation: Montreal, Quebec, Canada
  • Year and Date: 20080912-20080916
• [Presentation] Predictive capacity of biochemical markers of bone turnover and endogenous hormones for osteoporosis in men : ten-year follow-up of a Japanese cohort (2008)
  • Author(s): Yoshimura N, Oka H, Muraki S, Akune T, Kawaguchi H, Nakamura K
  • Organizer: 30th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
  • Place of Presentation: Montreal, Quebec, Canada
  • Year and Date: 20080912-20080916
• [Presentation] Development of high-throughput screening system for osteogenic drugs using cell-based sensor (2008)
  • Author(s): Hojo H, Igawa K, Ohba S, Yano F, Nakajima K, Komiyama K, Yonezawa T, Woo JT, Lichtler AC, Rowe DW, Ikeda T, Nakamura K, Kawaguchi H, Chung UI
  • Organizer: 30th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
  • Place of Presentation: Montreal, Quebec, Canada
  • Year and Date: 20080912-20080916
• [Presentation] Prevalence and risk factors for radiographic osteoarthritis of the knee and lumbar spine in Japan : The Research on Osteoarthritis Against Disability (ROAD) Study (2008)
  • Author(s): Yoshimura N, Muraki S, Oka H, Akune T, Mabuchi A, En-yo Y, Yoshida M, Suzuki T, Yoshida H, Kawaguchi H, Nakamura K
  • Organizer: 35th European Symposium on Calcified Tissues (ECTS)
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 20080524-20080528
• [Presentation] 変形性膝関節症 : その課題とアプローチの現状 (プレナリーレクチャー) (2008)
  • Author(s): 中村耕三, 川口浩, 吉村典子, 阿久根徹, 岡敬之, 村木重之, 馬淵昭彦
  • Organizer: 第52回日本リウマチ学会総会・学術集会
  • Place of Presentation: 北海道厚生年金会館、北海道
  • Year and Date: 20080420-20080423
• [Presentation] マウスジェネティクスを用いた変形性関節症の分子メカニズムの解明 (シンポジウム : 骨・軟骨疾患の分子生物学) (2007)
  • Author(s): 川口浩
  • Organizer: 第30回日本分子生物学会・第80回日本生化学学会 合同大会 (BMB2007)
  • Place of Presentation: パシフィコ横浜、神奈川
  • Year and Date: 20071211-20071215
• [Presentation] Transcriptional regulation of cartilage degeneration from a mouse OA model (invited lecture) (2007)
  • Author(s): Kawaguchi H
  • Organizer: 2007 World Congress on Osteoarthritis (OARSI)
  • Place of Presentation: Ft. Lauderdale, Florida, USA
  • Year and Date: 20071206-20071209
• [Presentation] Transcriptional induction of type X collagen expression and hypertrophic differentiation of chondrocytes by Runx2 during osteoarthritis progression (Young Investigator Award) (2007)
  • Author(s): Higashikawa A, Saito T, Kamekura S, Ohba S, Ikeda T, Nakamura K, Chung UI, Kawaguchi H
  • Organizer: 2007 World Congress on Osteoarthritis (OARSI)
  • Place of Presentation: Ft. Lauderdale, Florida, USA
  • Year and Date: 20071206-20071209
• [Presentation] Risk factors for radiographic knee osteoarthritis and lumbar spomdylosis : the ROAD study (Young Investigator Award) (2007)
  • Author(s): Muraki S, Oka H, Mabuchi A, En-yo Y, Yoshida M, Saiga A, Nakamura K, Kawaguchi H, Yoshimura N
  • Organizer: 2007 World Congress on Osteoarthritis (OARSI)
  • Place of Presentation: Ft. Lauderdale, Florida, USA
  • Year and Date: 20071206-20071209
• [Presentation] Fully automatic quantification of knee osteoarthritis severity on standard radiographs by a novel computer-assisted system (2007)
  • Author(s): Oka H, Yoshimura N, Muraki S, Mabuchi A, Nakamura K, Kawaguchi H
  • Organizer: 2007 World Congress on Osteoarthritis (OARSI)
  • Place of Presentation: Ft. Lauderdale, Florida, USA
  • Year and Date: 20071206-20071209
• [Presentation] Identification of sorting nexin 19 as a novel chondrogenic factor by a real-time fluorescence monitoring cell line ATDC5-S2RD5 (Young Investigator Award) (2007)
  • Author(s): Kan A, Ikeda T, Saito T, Ushita M, Nakamura K, Chung UI, Kawaguchi H
  • Organizer: 2007 World Congress on Osteoarthritis (OARSI)
  • Place of Presentation: Ft. Lauderdale, Florida, USA
  • Year and Date: 20071206-20071209
• [Presentation] Local application of recombinant human fibroblast growth factor-2 on bone repair (2007)
  • Author(s): Kawaguchi H
  • Organizer: The 6th Combined Meeting of the Orthopaedic Research Societies
  • Place of Presentation: Honolulu, Hawaii, USA
  • Year and Date: 20071020-20071024
• [Presentation] Cartilage differentiation and osteoarthritis (2007)
  • Author(s): Kawaguchi H
  • Organizer: 19th Annual Meeting of the Korean Society for Molecular Cell Biology (Symposium : Cartilage and Bone)
  • Place of Presentation: Seoul, Korea
  • Year and Date: 20071018-20071019
• [Presentation] GSK-3β inhibits osteoblastic bone formation through suppression of Runx2 transcriptional activity by the phosphorylation at a specific site (Young Investigator Award) (2007)
  • Author(s): Hirata M, Kugimiya F, Kawamura N, Ohba S, Nakamura K, Kawaguchi H, Chung UI
  • Organizer: 29th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
  • Place of Presentation: Honolulu, Hawaii, USA
  • Year and Date: 20070916-20070919
• [Presentation] Hypoxia-inducible factor 2α induces type X collagen and promotes hypertrophic differentiation of chondrocytes (2007)
  • Author(s): Saito T, Ikeda T, Higashikawa A, Kawasaki Y, Kan A, Ushita M, Ohba S, Yano F, Nakamura K, Chung UI, Kawaguchi H
  • Organizer: 29th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
  • Place of Presentation: Honolulu, Hawaii, USA
  • Year and Date: 20070916-20070919
• [Presentation] Identification of a novel chondrogenic factor Sorting Nexin 19 using a real-time fluorescence monitoring cell line ATDC5-S2RD5 (2007)
  • Author(s): Kan A, Ikeda T, Saito T, Chung UI, Kawaguchi H
  • Organizer: 29th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
  • Place of Presentation: Honolulu, Hawaii, USA
  • Year and Date: 20070916-20070919
• [Presentation] Transcriptional induction of SOX9 by NF-κB subunit p65 during chondrogenesis (2007)
  • Author(s): Ushita M, Ikeda T, Saito T, Kan A, Nakamura K, Chung UI, Kawaguchi H
  • Organizer: 29th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
  • Place of Presentation: Honolulu, Hawaii, USA
  • Year and Date: 20070916-20070919
• [Presentation] Transcriptional regulation of type X collagen by Runx2 : Molecular network underlying chondrocyte hypertrophy causing osteoarthritis (2007)
  • Author(s): Higashikawa A, Saito T, Kamekura S, Ohba S, Ikeda T, Nakamura K, Chung UI, Kawaguchi H
  • Organizer: 29th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
  • Place of Presentation: Honolulu, Hawaii, USA
  • Year and Date: 20070916-20070919
• [Presentation] Runx1, co-activator of Sox5, Sox6 and Sox9 (the Sox trio) regulates chondrogenic differentiation (2007)
  • Author(s): Yano F, Ikeda T, Saito T, Ogata N, Takeda S, Kimura A, Ohba S, Kugimiya F, Nakamura K, Takato T, Kawaguchi H, Chung UI
  • Organizer: 29th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
  • Place of Presentation: Honolulu, Hawaii, USA
  • Year and Date: 20070916-20070919
• [Presentation] p63 plays a central role in cartilage development by directly regulating key genes for chondrogenesis (2007)
  • Author(s): Ikeda T, Kawaguchi H, Saito T, Kan A, Yano F, Ushita M, Kawasaki Y, Nakamura K, Chung UI
  • Organizer: 29th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
  • Place of Presentation: Honolulu, Hawaii, USA
  • Year and Date: 20070916-20070919
• [Presentation] Is osteoporosis related to future incidence of osteoarthritis over 10 years, or vice-versa? (2007)
  • Author(s): Yoshimura N, Muraki S, Oka H, Mabuchi A, Kawaguchi H, Nakamura K
  • Organizer: 29th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
  • Place of Presentation: Honolulu, Hawaii, USA
  • Year and Date: 20070916-20070919
• [Presentation] Prevalence of radiographic osteoarthritis of knee and lumbar spine and its association with pain : The Research on Osteoarthritis Against Disability (ROAD) study (2007)
  • Author(s): Muraki S, Yoshimura N, Oka H, Mabuchi A, En-yo Y, Yoshida M, Suzuki T, Yoshida H, Ishibashi H, Yamamoto S, Kawaguchi H, Nakamura K
  • Organizer: 29th annual meeting of the American Society for Bone and Mineral Research (ASBMR)
  • Place of Presentation: Honolulu, Hawaii, USA
  • Year and Date: 20070916-20070919
• [Presentation] Full-automatic measurement of knee osteoarthritis parameters by a novel computer-assisted system on standard radiographs (2007)
  • Author(s): Oka H, Yoshimura N, Muraki S, Mabuchi A, Nakamura K, Kawaguchi H
  • Organizer: 1st Workshops on Imaging-Based Measures of Osteoarthritis
  • Place of Presentation: Salzburg & Ainring, Germany
  • Year and Date: 20070711-20070714
• [Presentation] Insulin/IRS/Akt signaling for maintainance of bone mass and turnover. (Symposia : Mediators of PTH action) (2007)
  • Author(s): Kawaguchi H
  • Organizer: The Endocrine Society's 89th Annual Meeting (ENDO 07)
  • Place of Presentation: Toronto, Canada
  • Year and Date: 20070602-20070605
• [Presentation] Association of radiographic osteoarthritis of knee and lumbar spine with pain. The Research on Osteoarthritis Against Disability (ROAD) study (2007)
  • Author(s): Muraki S, Yoshimura N, Oka H, Mabuchi A, En-Yo Y, Yoshida M, Saika A, Suzuka T, Yoshida H, Ishibashi H, Yamamoto S, Kawaguchi H, Nakamura K
  • Organizer: 34th annual meeting of the European Calcified Tissue Society (ECTS)
  • Place of Presentation: Copenhagen, Denmark
  • Year and Date: 20070505-20070509
• [Presentation] Osteoporosis and osteoarthritis: is osteoporosis a predictor of the incidence of osteoarthritis or vice versa? (2007)
  • Author(s): Yoshimura N, Muraki S, Oka H, Mabuchi A, Kawaguch H, Nakamura K
  • Organizer: 34th annual meeting of the European Calcified Tissue Society (ECTS)
  • Place of Presentation: Copenhagen, Denmark
  • Year and Date: 20070505-20070509
• [Book] 新国民病ロコモティブシンドローム 長寿社会は警告する (2010)
  • Author(s): 中村耕三
  • Total Pages: 315
  • Publisher: NHK出版生活人新書
• [Book] ロコモティブシンドローム (監修)「BS朝日テレビテキスト「医療の現場! 4」 (2010)
  • Author(s): 中村耕三
  • Total Pages: 20-35
• [Book] ロコモティブシンドローム特集にあたって (巻頭言)「Modern Physician 30」 (2010)
  • Author(s): 中村耕三
  • Total Pages: 461-463
• [Book] 特集 ロコモティブシンドローム-予防・治療のための運動支援- (巻頭言)「臨床スポーツ医学 27」 (2010)
  • Author(s): 中村耕三
• [Book] 関節・軟骨疾患の分子医学 : 変形性関節症の治療標的分子の探索. BIO CLINICA (特集 : 骨・軟骨疾患の分子医学) (2010)
  • Author(s): 川口浩
  • Total Pages: 41-45
• [Book] 変形性関節症の治療ガイドライン. Geriatric Medicine 老年医学 (特集 : 変形性関節症・脊椎症)-診断と治療の最前線- (2010)
  • Author(s): 川口浩
  • Total Pages: 307-314
• [Book] 高齢社会におけるロコモティブシンドローム「運動療法と物理療法 20」 (2009)
  • Author(s): 中村耕三
  • Total Pages: 300-304
• [Book] 筋肉・バランス感覚「NHKここが聞きたい! 名医にQロコモティブシンドローム](共同監修) (2009)
  • Author(s): 中村耕三, 遠藤直人, 宗田大
  • Publisher: 日本放送出版協会
• [Book] ひざ痛・骨粗しょう症の新常識! ロコモティブシンドローム (監修)「NHKテレビテキスト きょうの健康4」 (2009)
  • Author(s): 中村耕三
  • Total Pages: 50-61
• [Book] Osteovisual「変形性関節症における軟骨破壊のメカニズム」. Arthritis (2009)
  • Author(s): 川口浩
  • Total Pages: 149-153
• [Book] 遺伝子変異マウスによる変形性関節症の病態解明へのアプローチ. The Bone (特集 : 変形性関節症の基礎と臨床) (2009)
  • Author(s): 川口浩
  • Total Pages: 35-40
• [Book] 変形性関節症 : 研究・診療の現状と問題点. 日本老年病学会雑誌 (骨粗鬆症と変形性関節症 : 研究と診療の最前線) (2009)
  • Author(s): 川口浩
  • Total Pages: 121-127
• [Book] 変形性関節症に対する分子標的治療の展望. CLINICAL CALCIUM (特集 : 変形性関節症 Up-to-date) (2009)
  • Author(s): 川口浩
  • Total Pages: 1608-1614
• [Book] 変形性関節症の疫学研究の現状と問題点 : ROAD (Research on Osteoarthritis Against Disability) 研究. 日本整形外科学会雑誌 (シンポジウム : 変形性膝関節症のマネージメント-最新の臨床エビデンスとエキスパートオピニオン-) (2009)
  • Author(s): 川口浩, 阿久根徹, 村木重之, 岡敬之, 中村耕三, 吉村典子
  • Total Pages: 978-981
• [Book] 変形性関節症 : ROAD 研究が明らかにした実態. 日経メディカル (特集 : 骨粗鬆症と運動器不安定症) (2008)
  • Author(s): 川口浩, 阿久根徹, 岡敬之, 村木重之, 中村耕三, 吉村典子
  • Total Pages: 29-31
• [Book] 変形性関節症の治療標的分子の解明. 骨の remodeling における Dickkopf-1 の役割. リウマチ科 (特集 : 変形性関節症の病態と治療-最近の進歩) (2008)
  • Author(s): 川口浩
  • Total Pages: 498-505
• [Book] OARSIによる股・膝関節OAの治療ガイドライン. Osteoarthritis Update (特集 : 変形性関節症の最新知見) (2008)
  • Author(s): 川口浩
  • Total Pages: 2-5
• [Book] 世界におけるOAの疫学. Osteoarthritis Update (特集 : 変形性関節症の最新知見) (2008)
  • Author(s): 村木重之, 川口浩
  • Total Pages: 10-13
• [Book] OAの画像診断. Osteoarthritis Update (特集 : 変形性関節症の最新知見) (2008)
  • Author(s): 岡敬之, 川口浩
  • Total Pages: 18-21
• [Book] 「運動器リハビリテーションクルズス」第1章 運動を司る構造と機能 : 解剖・生理について. I. 筋骨格系骨. 1. 骨の構造と機能(編集 : 岩谷力、黒沢尚、江藤文夫、赤居正美、星野雄一、飛松好子) (2008)
  • Author(s): 川口浩
  • Total Pages: 7-11
  • Publisher: 南江堂
• [Book] 軟骨のメカニカルストレスと変形性関節症. CLINICAL CALCIUM (特集 : メカニカルストレスと骨) (2008)
  • Author(s): 川口浩
  • Total Pages: 1278-1286
• [Book] コンピュータを用いた大腿骨頸部骨形態自動計測法の開発. Osteoporos Jpn (2008)
  • Author(s): 村木重之, 阿久根徹, 岡敬之, 吉村典子
  • Total Pages: 644-647
• [Book] 変形性関節症の疫学研究. 日本整形外科学会雑誌 (シンポジウム : 変形性関節症の病態解明・診断・治療の新世紀) (2007)
  • Author(s): 吉村典子, 岡敬之, 村木重之, 馬淵昭彦, 延與良夫, 吉田宗人, 鈴木隆雄, 山本精三, 川口浩, 中村耕三
  • Total Pages: 17-21
• [Patent(Industrial Property Rights)] 膝関節診断支援方法及び装置並びにプログラム
  • Inventor(s): 中村耕三, 川口浩, 岡敬之
  • Industrial Property Rights Holder: 中村耕三, 川口浩, 岡敬之
  • Patent Publication Number: 特開2008-93229