2010 Fiscal Year Final Research Report
Study of Rhythm Formation Mechanism in Brainstem by Statistical Analysis of Spatio-Temporal Voltage Imaging Data
| Project/Area Number |
19200021
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Statistical science
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| Research Institution | The Institute of Statistical Mathematics |
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Principal Investigator |
ISHIGURO Makio The Institute of Statistical Mathematics, 名誉教授 (10000217)
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| Co-Investigator(Kenkyū-buntansha) |
OKADA Yasumasa 慶應義塾大学, 医学部, 准教授 (80160688)
OKU Yoshitaka 兵庫医科大学, 医学部, 教授 (20252512)
TAMURA Yoshiyasu 統計数理研究所, データ科学系, 教授 (60150033)
MIWAKEICHI Fumikazu 統計数理研究所, モデリング研究系, 准教授 (30360647)
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| Project Period (FY) |
2007 – 2010
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| Keywords | 非線形入力モデル / 因果関係 / ニューロンの分類 / データ重ねあわせ / SN比の改善 / 過渡的現象の解析 / 情報量規準 / 画像データ解析 |
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| Research Abstract |
To assess the spatiotemporal dynamics of respiratory-related regions of the ventral medulla, we optically recorded the respiratory neuronal network activity of the ventral medulla of the in vitro brainstem-spinal cord preparation using a voltage-sensitive dye, and developed a novel non-linear response model called the Sigmoid and Transfer Function model (STF model) which regards the respiratory motor activity recorded from the fourth cervical ventral root (C4VR) of the spinal cord as the response to optical signals from pixels within respiratory-related regions. Then we developed a new filtering method to detect respiration-related activity in the area. The result was published in a top journal in medical imaging.
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[Presentation] Desynchronization of bursting neurons in the preBotzinger complex may produce quantal slowing of the respiratory rhythm2008
Author(s)
Lal A., Oku Y., Fresemann J., Hulsmann S., Okada, Y., Miwakeichi F, Kawai S., Tamura Y., Ishiguro, M.
Organizer
The International Discussion Forum & the 242nd Tokyo Discussion Meeting of the Physiological Society of Japan
Place of Presentation
Tokyo
Year and Date
2008-10-26
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