2010 Fiscal Year Final Research Report
in silico analysis of molecular interactions between commercially available drugs in Japan and proteins
| Project/Area Number |
19200024
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bioinformatics/Life informatics
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| Research Institution | Tokai University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MUTA Hajime (80384923)
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| Project Period (FY) |
2007 – 2010
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| Keywords | 医薬分子 / タンパク質 / 分子認識 / ドッキング / 分子力学 |
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| Research Abstract |
Understanding of modes of interactions between drugs and proteins is important to promote drug discovery and studies on side-effects of drugs. Although it is not practically possible to measure all the interactions experimentally, in silico methods are expected to become viable alternatives. In this project, we have studied novel methodologies essential for this purpose, and applied them to evaluate the interactions between commercially available drugs and proteins which are closely related to carbohydrate metabolism.
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