Synapse formation and maintenance in adult brain : characterization of a new anterograde signal

2009 Fiscal Year Self-evaluation Report

• Project/Area Number: 19200026
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neuroscience in general
• Research Institution: Keio University
• Principal Investigator: YUZAKI Michisuke Keio University, 医学部, 教授 (40365226)
• Project Period (FY): 2007 – 2010
• Keywords: 分子 / 細胞神経科学

Research Abstract

神経回路網はいったん完成したあとも、生涯にわたって神経活動に応じてシナプス結合強度を変化させ、長期増強(LTP)・長期抑圧(LTD)といったシナプス可塑性を示す。このような機能的な可塑性に加えて、成熟脳においてもシナプスの形態的変化が起きることが、近年判明してきた。しかし、このような成熟脳における機能的可塑性を支える分子的基盤については未だに不明な点が多い。
私たちは小脳プルキンエ細胞に特異的に発現するδ2型グルタミン酸受容体(δ2受容体)と、小脳顆粒細胞から分泌されるCbln1は、機能的および形態的可塑性をそれぞれ制御することを見いだした。本研究ではこの2つの分子に着目して、成熟脳における機能的・形態的シナプス可塑性機構を明らかにすることを目的とした。

Research Products

• [Journal Article] Cbln1 is a ligand for an orphan glutamate receptor δ2, a bidirectional synapse organizer (2010)
  • Author(s): Matsuda K, Miura E, Miyzaki T, Kakegawa, W, Emi K, Narumi S, Fukazawa Y, Ito-Ishida A, Kondo T, Shigemoto R, Watanabe M, Yuzaki M
  • Journal Title: Science 328 Pages: 363-368
• [Journal Article] The N-terminal domain of GluD2 (GluRδ2) recruits presynaptic terminals and regulates synaptogenesis in the cerebellum in vivo (2009)
  • Author(s): Kakegawa W, Miyazaki T, Kohda K, Matsuda K, Emi K, Motohashi J, Watanabe M, Yuzaki M
  • Journal Title: J.Neurosci. 29 Pages: 5738-5748
• [Journal Article] Activity-dependent repression of Cbln1 expression: mechanism for developmental and homeostatic regulation of synapses in the cerebellum (2009)
  • Author(s): Iijima T, Emi K, Yuzaki M
  • Journal Title: J.Neurosci. 29 Pages: 5425-5434
• [Journal Article] Cbln1 regulates rapid formation and maintenance of excitatory synapses in mature cerebellar Purkinje cells in vitro and in vivo. (2008)
  • Author(s): Ito-Ishida A, Miura E, Emi K, Matsuda K, Iijima T, Kondo T, Kohda K, Watanabe M, Yuzaki M
  • Journal Title: J.Neurosci. 28 Pages: 5920-5930
• [Journal Article] Differential regulation of synaptic plasticity and cerebellar motor learning by the C-terminal PDZ-binding motif of GluRδ2 (2008)
  • Author(s): Kakegawa W, Miyazaki T, Emi K, Matsuda K, Kohda K, Motohashi J, Mishina M, Kawahara S, Watanabe M, Yuzaki M
  • Journal Title: J.Neurosci. 28 Pages: 1460-1468
• [Presentation] Cbln1 and its receptor: a unique and essential bidirectional synaptic organizer complex. (2010)
  • Author(s): Yuzaki M
  • Organizer: Invited Talk at the Keystone Symposia on Synapses: Formation, Function and Misfunction
  • Place of Presentation: Snowbird, Utah, USA
  • Year and Date: 2010-04-13
• [Presentation] Cbln family proteins and their receptors: unique presynaptic organizers in the cerebellum and hippocampus. (2009)
  • Author(s): Yuzaki M
  • Organizer: Selected Talk at the Gordon Conference on Excitatory Synapses and Brain Function
  • Place of Presentation: Les Diablerets, Switzerland
  • Year and Date: 2009-09-08
• [Presentation] Toward functional recovery of neuronal circuits-two new molecules regulating formation and maintenance of synapses in adult brain. (2008)
  • Author(s): Yuzaki M
  • Organizer: The 2nd Symposium on Brain and Mind Research in the Asia/Pacific (BMAP)
  • Place of Presentation: Singapore
  • Year and Date: 2008-09-02
• [Book] Glutamate Receptors : NMDA and Delta Receptors.Handbook of Neurochemistry and Molecular Neurobiology (2009)
  • Author(s): Yuzaki M
  • Publisher: Springer
• [Book] Delta receptors.The Glutamate Receptors.(Gereau, R.W., and Swanson, G.T. eds) (2008)
  • Author(s): Yuzaki M
  • Publisher: The Humana Press