2010 Fiscal Year Final Research Report
Synapse formation and maintenance in adult brain : characterization of a new anterograde signal
| Project/Area Number |
19200026
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (A)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Neuroscience in general
|
|---|
| Research Institution | Keio University |
|---|
Principal Investigator |
YUZAKI Michisuke Keio University, 医学部, 教授 (40365226)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KOHDA Kazuhisa 慶應義塾大学, 医学部, 講師 (40334388)
KAKEGAWA Wataru 慶應義塾大学, 医学部, 助教 (70383718)
|
|---|
| Project Period (FY) |
2007 – 2010
|
| Keywords | シナプス形成 / 記憶 / 長期抑圧 / 小脳 / シナプス可塑性 / グルタミン酸受容体 |
|---|
| Research Abstract |
Memories are believed to be stored as functional and morphological changes at synapses. To understand the underlying molecular mechanisms, we focused on two molecules, the δ2 glutamate receptor and Cbln1, which play essential roles in cerebellar functions, including motor memory. We found that Cbln1, released from cerebellar granule cells, binds directly to the amino terminus of the δ2 receptor and regulate synapse formation. Furthermore, the carboxyl terminus of the δ2 receptor regulates induction of functional synaptic plasticity.
|
-
-
-
-
[Journal Article] Cbln1 is a ligand for an orphan glutamate receptor ・2, a bidirectional synapse organizer.2010
Author(s)
Matsuda K, Miura E, Miyzaki T, Kakegawa, W, Emi K, Narumi S, Fukazawa Y, Ito-Ishida A, Kondo T, Shigemoto R, Watanabe M, Yuzaki M
-
Journal Title
Science 328
Pages: 363-368
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
