• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2009 Fiscal Year Self-evaluation Report

Regulatory mechanism of synaptic function by actin and its role in higher brain function

Research Project

  • PDF
Project/Area Number 19200029
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurochemistry/Neuropharmacology
Research InstitutionGunma University

Principal Investigator

SHIRAO Tomoaki  Gunma University, 大学院・医学系研究科, 教授 (20171043)

Project Period (FY) 2007 – 2010
Keywordsシナプス形態形成 / アクチン / ドレブリン / 神経細胞培養 / 行動分析 / シナプス機能
Research Abstract

「樹状突起スパイン内アクチン結合蛋白の量的・質的動態」と「神経伝達物質受容体や足場蛋白のシナプス後部への集積」との双方向性の制御を分子レベルで解析し、アクチンによるシナプス機能制御のメカニズムを明らかにする。そして、このメカニズムの破綻がもたらすシナプス機能不全及び高次脳機能障害を、遺伝子変換マウスを用いて解析することにより、当該メカニズムの高次脳機能における役割を明らかにする。

  • Research Products

    (6 results)

All 2010 2009 2008 2007

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (1 results)

  • [Journal Article] Genetic disruption of the alternative splicing of drebrin gene impairs context-dependent fear learning in adulthood2010

    • Author(s)
      Kojima N, Hanamura K, Yamazaki H, Ikeda T, Itohara S, Shirao T.
    • Journal Title

      Neuroscience 165

      Pages: 138-150

    • Peer Reviewed
  • [Journal Article] AMPA receptor inhibition causes abnormal dendritic spines by destabilizing drebrin2009

    • Author(s)
      Takahashi, T, Yamazaki, H, Hanamura K, Sekino Y, Shirao T
    • Journal Title

      J Cell Sci. 122

      Pages: 1211-1229

    • Peer Reviewed
  • [Journal Article] Drebrin E is involved in the mechanism regulating axonal growth through actin-myosin interactions2009

    • Author(s)
      Mizui T., Kojima N, Yamazaki H, Katayama M, Hanamura K, Shirao T.
    • Journal Title

      J Neurochem 109

      Pages: 611-622

    • Peer Reviewed
  • [Journal Article] Expression of drebrin E in migrating neuroblasts in adult rat brain : coincidence between drebrin E disappearance from cell body and cessation of migration2008

    • Author(s)
      Song M, Kojima N, Hanamura K, Sekino Y, Inoue KH, Mikuni M, Shirao T.
    • Journal Title

      Neuroscience 152

      Pages: 670-682

    • Peer Reviewed
  • [Journal Article] Drebrin A content correlates with spine head size in the adult mouse cerebral cortex2007

    • Author(s)
      Kobayashi, C., Aoki, C., Kojima, N., Yamazaki, H., Shirao, T.
    • Journal Title

      J. Comp. Neurol. 503

      Pages: 618-626

    • Peer Reviewed
  • [Presentation] Regulation of dendritic spine morphology by changing drebrin-A dynamics2009

    • Author(s)
      Shirao, T., Hanamura, K., Takahashi, H., Mizui, T., Sekino, Y.
    • Organizer
      21th ISN Biennial Meeting
    • Place of Presentation
      Busan, Korea
    • Year and Date
      2009-08-23

URL: 

Published: 2011-06-18   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi