2009 Fiscal Year Final Research Report
Mechanisms of the development of neuronal cell community in the central nervous system
| Project/Area Number |
19200031
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Keio University |
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Principal Investigator |
NAKAJIMA Kazunori Keio University, 医学部, 教授 (90280734)
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| Co-Investigator(Kenkyū-buntansha) |
SAKAKIBARA Yasubumi 慶應義塾大学, 理工学部, 教授 (10287427)
TABATA Hidenori 慶應義塾大学, 医学部, 専任講師 (80301761)
OISHI Koji 慶應義塾大学, 医学部, 助教 (80420818)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 大脳皮質 / 発生・分化 / 神経科学 / 脳・神経 / 細胞移動 |
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| Research Abstract |
We have focused on the migration process of neocortical neurons and identified many genes that are preferentially expressed in cells just beneath the marginal zone. In addition, we have identified functions of several genes in layer formation and migrating cell dynamics. We have also found the differences of migratory behavior between direct progeny of apical progenitors and basal progenitors in the developing neocortex. The former stay above the ventricular zone for almost 1 day, where we named the multipolar cell accumulation zone (MAZ).
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