2010 Fiscal Year Final Research Report
Measurement and control of cellular functions using spatio-temporal electrical stimulation
| Project/Area Number |
19200036
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (A)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Biomedical engineering/Biological material science
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
JIMBO Yasuhiko The University of Tokyo, 大学院・新領域創成科学研究科, 教授 (20372401)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MABUCHI Kunihiko 東京大学, 大学院・工学系研究科, 教授 (50192349)
SAKUMA Ichiro 東京大学, 大学院・情報理工学系研究科, 教授 (50178597)
|
|---|
| Project Period (FY) |
2007 – 2010
|
| Keywords | 生体情報・計測 / 電気刺激 / 細胞 |
|---|
| Research Abstract |
Modification of cellular activity induced by spatio-temporal electrical stimulation was studied. Continuous application of2Hz stimulus for12hours elicited approximately the same contraction rhythm in cultured cardiomyocytes. In cultured cortical neurons, the history of spatio-temporal stimulation was reflected in their evoked responses. A novel microcavity-array device was developed for ensemble stimulation of embryoid bodies of stem cells. Intracellular calcium transients were elicited by the stimulus, which would be promising as a tool for regulating cell differentiation.
|
-
[Journal Article] Device for co-culture of sympathetic neurons and cardiomyocytes using micro-fabrication2011
Author(s)
Takeuchi A., Nakafutami S., Tani H., Mori M., Takayama Y., Moriguchi H., Kotani K., Miwa K., Lee J., Noshiro M., Jimbo Y.
-
Journal Title
Lab Chip DOI:10
Pages: 1039 /C0LC00327A
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
