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2009 Fiscal Year Final Research Report

Creation of growth factors binding to metal or ceramic for and their medical applications

Research Project

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Project/Area Number 19200041
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

ITO Yoshihiro  The Institute of Physical and Chemical Research, 伊藤ナノ医工学研究室, 主任研究員 (40192497)

Co-Investigator(Kenkyū-buntansha) ABE Hiroshi  独立行政法人理化学研究所, 伊藤ナノ医工学研究室, 専任研究員 (80415067)
WADA Akira  独立行政法人理化学研究所, 伊藤ナノ医工学研究室, 研究員 (90443051)
YOSHIDA Yasuhiro  岡山大学, 医歯(薬)学総合研究科, 准教授 (90281162)
KITAJIMA Takashi  独立行政法人理化学研究所, 伊藤ナノ医工学研究室, 協力研究員 (40399556)
Project Period (FY) 2007 – 2009
Keywordsバイオマテリアル / 表面処理 / 成長因子 / タンパク質工学 / リボソーム・ディスプレイ / ケミカルライゲーション法 / ミスアシル化tRNA法 / 非天然アミノ酸
Research Abstract

Design and synthesis for metal-or ceramic-binding growth factor proteins were performed. First, organic molecular coating was performed on titan or stainless steel for growth factor immobilization. Secondly, titan-or apatite-binding growth factor proteins were designed by molecular evolutionary engineering and chemical ligation using peptide carrying non-natural amino acid.

  • Research Products

    (53 results)

All 2010 2009 2008 2007 Other

All Journal Article (30 results) (of which Peer Reviewed: 23 results) Presentation (7 results) Book (11 results) Remarks (1 results) Patent(Industrial Property Rights) (4 results)

  • [Journal Article] Reprogramming of somatic cells induced by fusion of embryonic stem cells using hemagglutinating virus of Japan envelope (HVJ-E)2010

    • Author(s)
      X iao-shan Yue, Masako Fujishiro, Masashi Toyoda, Toshihiro Akaike, Yoshihiro Ito
    • Journal Title

      Biophys. Biochem. Res. Commun. (in press)

    • Peer Reviewed
  • [Journal Article] A photoimmobilizable sulfobetaine-based polymer for a nonbiofouling surface2010

    • Author(s)
      M akoto Sakuragi, Saki Tsuzuki, Sei Obuse, Akira Wada, Kenji Matoba, Izumi Kubo, Yoshihiro Ito
    • Journal Title

      Mater. Sci. Eng. C 30

      Pages: 316-322

    • Peer Reviewed
  • [Journal Article] 生体分子の固定化による機能性材料の創成-細胞成長因子の固定化は隔靴掻痒か?-2010

    • Author(s)
      伊藤嘉浩
    • Journal Title

      バイオマテリアル 28(1)

      Pages: 9-17

  • [Journal Article] 幹細胞培養用人工フィーダーの設計2009

    • Author(s)
      伊藤嘉浩、北嶋隆
    • Journal Title

      再生医療 8(2)

      Pages: 34-42

  • [Journal Article] Surface coating with a thermoresponsive copolymer for the culture and nonenzymatic recovery of mouse embryonic stem cells2009

    • Author(s)
      X ian Jun Loh, Jiansheng Gong, Makoto Sakuragi, Takashi Kitajima, Mingzhe Liu, Jun Li, Yoshihiro Ito
    • Journal Title

      Macromol. Biosci. 9

      Pages: 1069-1079

    • Peer Reviewed
  • [Journal Article] A chimeric epidermal growth factor with fibrin-affinity promotes repair injured keratinocyte sheets2009

    • Author(s)
      Takashi Kitajima, Hirokazu Hasuda, Makoto Sakuragi, Takeshi Ozu, Yoshihiro Ito
    • Journal Title

      Acta Biomater. 5

      Pages: 2623-2632

    • Peer Reviewed
  • [Journal Article] Novel poly(N-isopropylacrylamide)-poly[(R)-3-hydroxybutyrate]-poly(N-isopropylacrylamide) triblock copolymer surface as a culture substrate for human mesenchymal stem cells2009

    • Author(s)
      X ian Jun Loh, Wun Chet Davy Cheong, Jun Li, Yoshihiro Ito
    • Journal Title

      Soft Matter 5

      Pages: 2937-2946

    • Peer Reviewed
  • [Journal Article] Photo-immobilization of biological components on gold-coated chips for measurements using surface plasmon resonance (SPR) and a quartz crystal microbalance (QCM)2009

    • Author(s)
      S aki Tsuzuki, Akira Wada, Yoshihiro Ito
    • Journal Title

      Biotechnol. Bioeng. 102

      Pages: 700-707

    • Peer Reviewed
  • [Journal Article] Synthesis of a photoimmobilizable histidine polymer for surface modification2009

    • Author(s)
      M akoto Sakuragi, Saki Tsuzuki, Hirokazu Hasuda, Akira Wada, Kenji Matoba, Izumi Kubo, Yoshihiro Ito
    • Journal Title

      J. Apply. Polym. Sci. 112

      Pages: 315-319

    • Peer Reviewed
  • [Journal Article] 細胞制御材料と再生医療2009

    • Author(s)
      伊藤嘉浩、北嶋隆、阿部洋
    • Journal Title

      高分子 58(3)

      Pages: 129-132

  • [Journal Article] Peptide immobilized on gold particles enhances cell growth2008

    • Author(s)
      J iansheng Gong, Yoshihiro Ito
    • Journal Title

      Cytotechnology 58

      Pages: 141-144

    • Peer Reviewed
  • [Journal Article] Ribosome display selection of a metal-binding motif from an artificial peptide library2008

    • Author(s)
      A kira Wada, Shinya Y. Sawata, Yoshihiro Ito
    • Journal Title

      Biotechnol. Bioeng. 101

      Pages: 1102-1107

    • Peer Reviewed
  • [Journal Article] A Fusion Protein of Hepatocyte Growth Factor Enhances Reconstruction of Myocardium in a Cardiac Patch Derived from Porcine Urinary Bladder Matrix2008

    • Author(s)
      T akeyoshi Ota, Thomas W. Gilbert, David Schwartzman, Charles F. McTiernan, Takashi Kitajima, Yoshihiro Ito, Yoshiki Sawa, Stephen F. Badylak, Marco A. Zenati
    • Journal Title

      J. Thora. Cardio. Surg. 136

      Pages: 1309-1317

    • Peer Reviewed
  • [Journal Article] Chondrogenic differentiation of human mesenchymal stem cells on photoreactive polymer-modified surfaces2008

    • Author(s)
      L. Guo, N. Kawazoe, Y. Fan, Y. Ito, J. Tanaka, T. Tateishi, X. Zhang, G. Chen
    • Journal Title

      Biomaterials 29

      Pages: 23-32

    • Peer Reviewed
  • [Journal Article] ナノ界面テクノロジーによる機能表面創出2008

    • Author(s)
      伊藤嘉浩
    • Journal Title

      高分子論文集 65

      Pages: 6-19

    • Peer Reviewed
  • [Journal Article] Covalently immobilized biosignal molecule materials for tissue engineering2008

    • Author(s)
      Y. Ito
    • Journal Title

      Soft Matter 4(1)

      Pages: 46-56

    • Peer Reviewed
  • [Journal Article] 細胞成長因子の作用機序2008

    • Author(s)
      伊藤嘉浩
    • Journal Title

      日本臨床 66(5)

      Pages: 873-880

  • [Journal Article] 幹細胞:再生医療への期待2008

    • Author(s)
      伊藤嘉浩、今中応亘、北嶋隆
    • Journal Title

      バイオマテリアル 26(1)

      Pages: 11-22

  • [Journal Article] Modification of the titan surface with photoreactive gelatin to regulate cell attachment2007

    • Author(s)
      H. Mojgan, H. Hasuda, M. Sakuragi, Y. Yoshida, K. Suzuki, Y. Ito
    • Journal Title

      J. Biomed. Mater. Res. 83

      Pages: 906-914

    • Peer Reviewed
  • [Journal Article] A new nonbiofouling polyzwitterion including L-histidine2007

    • Author(s)
      T. Ishii, A. Wada, S. Tsuzuki, M. Casolaro, Y. Ito
    • Journal Title

      Biomacromolecules 8

      Pages: 3340-3344

    • Peer Reviewed
  • [Journal Article] Surface modification of plastic, glass and titanium by photoimmobilization of polyethylene glycol for antibiofouling2007

    • Author(s)
      Y. Ito, H. Hasuda, M. Sakuragi, S. Tsuzuki
    • Journal Title

      Acta Biomater. 3

      Pages: 1024-1032

    • Peer Reviewed
  • [Journal Article] Hepatocyte growth factor fusion protein having collagen-binding activity (CBD-HGF) accelerates re-endoethelialization and intimal hyperplasia in balloon-injured rat carotid artery2007

    • Author(s)
      N. Ohkawara, H. Ueda, S. Shinozaki, T. Kitajima, Y. Ito, H. Asaoka, A. Kawakami, E. Kaneko, K. Shimokado
    • Journal Title

      J. Atheroscler Thromb. 14

      Pages: 185-191

    • Peer Reviewed
  • [Journal Article] Grid pattern of nanothick microgel network2007

    • Author(s)
      G. Chen, N. Kawazoe, Y. Fan, Y. Ito, T. Tateishi
    • Journal Title

      Langmuir 23

      Pages: 5864-5867

    • Peer Reviewed
  • [Journal Article] A fusion protein of hepatocyte growth factor for immobilization to collagen2007

    • Author(s)
      T. Kitajima, H. Terai, Y. Ito
    • Journal Title

      Biomaterials 28

      Pages: 1989-1997

    • Peer Reviewed
  • [Journal Article] The movement of a water droplet on a gradient surface prepared by photodegradation2007

    • Author(s)
      Y. Ito, M. Heydari, A. Hashimoto, T. Konno, A. Hirasawa, S. Hori, K. Kurita, A. Nakajima
    • Journal Title

      Langmuir 23

      Pages: 1845-1850

    • Peer Reviewed
  • [Journal Article] Chemically fixed nurse cells for culturing murine or primate embryonic stem cells2007

    • Author(s)
      Y Ito, M. Kawamorita, T. Yamabe, T. Kiyono, K. Miyamoto
    • Journal Title

      J. Biosci. Bioeng. 103

      Pages: 113-121

    • Peer Reviewed
  • [Journal Article]2007

    • Author(s)
      W. Meng, S.-Y. Kim, J. Yuan, J.C. Kim, O.H. Kwon, N. Kawazoe, G. Chen, Y. Ito, I.-K. Kang
    • Journal Title

      Electrospun PHBV/collagen composite nanofibrous scaffolds for tissue engineering(J. Biomater. Sci., Polym. Edn.) 18

      Pages: 81-94

    • Peer Reviewed
  • [Journal Article] Electrospinning of microbial polyester for cell culture2007

    • Author(s)
      O. H. Kwon, I.S. Lee, Y.-G. Ko, W. Meng, K.-H. Jung, I.-K. Kang, Y. Ito
    • Journal Title

      Biomed. Mater. 2

      Pages: 1-7

    • Peer Reviewed
  • [Journal Article] 再生医療のための幹細胞増殖基材2007

    • Author(s)
      伊藤嘉浩
    • Journal Title

      膜 32(5)

      Pages: 276-280

  • [Journal Article] 幹細胞培養のためのナノ界面創成バイオリアクター2007

    • Author(s)
      伊藤嘉浩
    • Journal Title

      化学 62(7)

      Pages: 38-41

  • [Presentation] Design of nano-biointerfaces for medical devices2010

    • Author(s)
      Y. Ito
    • Organizer
      3rd Conference on Nanostructures (Sharif University of Technology)
    • Place of Presentation
      Kish Island, Iran
    • Year and Date
      20100300
  • [Presentation] Gene-engineered binding growth factors2009

    • Author(s)
      Y. Ito
    • Organizer
      2009 Meeting of the Korea Society for Biomaterials (The Korean Society for Biomaterials)
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      20091100
  • [Presentation] Differentiation control of stem cells by immobilized cytokines and chemical compounds2009

    • Author(s)
      Y. Ito
    • Organizer
      2009 China-Japan Regenerated Medical techniques Forum (The Chinese Academy of Sciences)
    • Place of Presentation
      Shanghai, China
    • Year and Date
      20090300
  • [Presentation] Combination of bimateraisl with growth factors for tissue engineering2008

    • Author(s)
      Y. Ito
    • Organizer
      International Workshop on Biomacromolecules 2008, (Royal Institute of Technology)
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      20080600
  • [Presentation] Biomaterials for culture of ES cells2007

    • Author(s)
      Y. Ito
    • Organizer
      1st Asian Biomaterials Congress
    • Place of Presentation
      Tsukuba
    • Year and Date
      20071200
  • [Presentation] Biological surface-modification of biomaterials for regenerative medicine2007

    • Author(s)
      Y. Ito
    • Organizer
      17th International Vacuum Congress (IVC-17)/13th International Conference on Surface Science and Technology (ICN+T2007)
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      20070700
  • [Presentation] Biocomposite Materials for Medical Applications2007

    • Author(s)
      Y. Ito
    • Organizer
      2007 International Advanced Drug Delivery Symposium (The industrial Technology Research Institute)
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      20070600
  • [Book] 幹細胞と再生医療、バイオマテリアルの基礎2010

    • Author(s)
      伊藤嘉浩
    • Publisher
      日本医学館(印刷中)
  • [Book] Comprehensive Biomaterials(Growth Factors and Protein Modified Surfaces and Interfaces)2010

    • Author(s)
      Yoshihiro Ito
    • Publisher
      Elsevier(in press)
  • [Book] Design of binding growth factors(G. Khang, ed., The Handbook of Intelligent Scaffold for Regenerative Medicine)2010

    • Author(s)
      Yoshihiro Ito
    • Publisher
      (印刷中)
  • [Book] マイクロアレイによる生体の相互作用解析、シングルセル解析の最前線2010

    • Author(s)
      伊藤嘉浩
    • Total Pages
      175-185
    • Publisher
      シーエムシー出版
  • [Book] Growth factors on biomaterial surfaces(Biological Interactions on Materials Surfaces: Understanding and Controlling Protein, Cell and Tissue Responses)2009

    • Author(s)
      Y. Ito
    • Total Pages
      173-197
  • [Book] ゲルコントロール-ゲルの上手な作り方とゲル化の抑制-(光架橋ゲルの応用-表面生体機能化-)2009

    • Author(s)
      伊藤嘉浩
    • Total Pages
      594-602
    • Publisher
      情報機構
  • [Book] 幹細胞の化学固定化培養システム、幹細胞の分化誘導と応用2009

    • Author(s)
      伊藤嘉浩
    • Total Pages
      91-98
    • Publisher
      エヌ・ティー・エス
  • [Book] Biomaterials in Asia(Biomaterials for stem cell cultures)2008

    • Author(s)
      Y. Ito
    • Total Pages
      116-139
  • [Book] 「幹細胞操作のためのバイオマテリアル」、「次世代医療のための高分子材料工学」2008

    • Author(s)
      伊藤嘉浩
    • Total Pages
      222-239
    • Publisher
      シーエムシー出版
  • [Book] 「細胞認識インターフェイス」、「環境調和型シリーズ生体材料」2008

    • Author(s)
      伊藤嘉浩
    • Total Pages
      361-368
    • Publisher
      日刊工業新聞
  • [Book] マイクロアレイ・バイオチップの最前線

    • Author(s)
      伊藤嘉浩監修
    • Publisher
      シーエムシー出版
  • [Remarks]

    • URL

      http://www.riken.jp/r-world/research/lab/wako/medical/index.html

  • [Patent(Industrial Property Rights)] 静電インクジェット現象を利用した三次元構造を有する細胞組織の作成2008

    • Inventor(s)
      梅津信二郎、北嶋隆、片平和俊、大森整、伊藤嘉浩
    • Industrial Property Rights Holder
      独立行政法人理化学研究所
    • Industrial Property Number
      特願2008-186068
    • Filing Date
      2008-07-17
  • [Patent(Industrial Property Rights)] 物質固定化用基板および物質固定化基板2008

    • Inventor(s)
      伊藤嘉浩、田代英夫
    • Industrial Property Rights Holder
      独立行政法人理化学研究所
    • Industrial Property Number
      特願2008-80292
    • Filing Date
      2008-03-26
  • [Patent(Industrial Property Rights)] 可視光硬化型接着剤2008

    • Inventor(s)
      伊藤嘉浩、孫泰一、田島右副
    • Industrial Property Rights Holder
      独立行政法人理化学研究所
    • Industrial Property Number
      特願2008-27930
    • Filing Date
      2008-02-07
  • [Patent(Industrial Property Rights)] 光反応性共重合体、表面改質剤、親水化処理剤、吸着抑制剤、物質固定化剤、表面改質方法、親水化方法、吸着抑制方法および物質固定化方法

    • Inventor(s)
      伊藤嘉浩
    • Industrial Property Rights Holder
      独立行政法人理化学研究所
    • Industrial Property Number
      特願2008-27128

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Published: 2011-06-18   Modified: 2016-04-21  

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